Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,071-5,080 of 5,253 results
Brain, 2022 • January 4, 2022
The study demonstrates that Celsr2, highly expressed in spinal motor neurons, inhibits axon regeneration. Inactivating Celsr2 in mice and human motor neurons promotes axon growth, fasciculation, and f...
KEY FINDING: Celsr2 knockout promotes axon regeneration and fasciculation in mouse cultured spinal explants and cultured Celsr2 mutant motor neurons extend longer neurites and larger growth cones.
Neurotherapeutics, 2021 • April 15, 2021
The study investigates the potential of a novel antisense oligonucleotide (NVP-13) to recondition the neurogenic niche in adult non-human primates by attenuating TGFβ signaling. NVP-13 effectively dow...
KEY FINDING: NVP-13 significantly downregulated TGFβ-RII mRNA and protein expression in vitro in human neural precursor cells.
Ann Rehabil Med, 2015 • June 1, 2015
This study investigated muscle stiffness in patients with early spinal cord injury (SCI) using acoustic radiation force impulse (ARFI) imaging. The findings indicated that patients with spasticity had...
KEY FINDING: Patients with spasticity had significantly faster shear wave velocities (SWV) in their gastrocnemius and biceps femoris muscles compared to those without spasticity and healthy controls.
Therapeutics and Clinical Risk Management, 2008 • January 1, 2008
The Rho-ROCK pathway is involved in many aspects of neuronal functions including neurite outgrowth and retraction. The effects of these inhibitors are reversed by blockade of the Rho-ROCK pathway in v...
KEY FINDING: Inhibition of the Rho-ROCK pathway reverses the effects of myelin-associated inhibitors, promoting axonal regeneration and functional recovery in the injured CNS in vivo.
Curr Pain Headache Rep, 2013 • January 1, 2013
Psychological screening and QST can help predict SCS outcomes. Psychological factors such as depression and anxiety are key predictors of success. QST measures, including pain thresholds and temporal ...
KEY FINDING: Psychological factors like somatization, depression, and anxiety are strong predictors of poor response to spinal cord stimulation.
Cell Prolif., 2022 • September 1, 2022
This review summarizes the pathological processes and mechanisms underlying inflammation, cell death and glial scar formation in secondary injury. In the acute phase of SCI, surgical intervention and ...
KEY FINDING: Early apoptosis and autophagy after TSCI protect against injury; prolonged inflammation leads to accumulation of pro-inflammatory factors and excessive apoptosis, aggravating TSCI.
Theranostics, 2024 • September 3, 2024
This study highlights a novel metabolic pathway involving MCT1-mediated lactate shuttling from endothelial cells to neurons, which is crucial for energy metabolism and axon regeneration after spinal c...
KEY FINDING: MCT1 expression is markedly decreased in endothelial cells (ECs) post-SCI, disrupting lactate transport to neurons.
Molecular Medicine Reports, 2018 • May 8, 2018
The study demonstrated that EA treatment has a beneficial effect on the pain threshold of rats undergoing CCI, increasing mechanical and thermal nociceptive thresholds. EA treatment significantly incr...
KEY FINDING: EA treatment significantly improved mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) in CCI model rats, indicating reduced pain.
The Journal of Neuroscience, 2014 • January 29, 2014
The study investigates the effects of transplanting Schwann cells (SCs) genetically modified to secrete a bifunctional neurotrophin (D15A) and chondroitinase ABC (ChABC) into a subacute contusion inju...
KEY FINDING: Transplantation of SCs secreting both D15A and ChABC yielded the best responses including the largest number of SC myelinated axons and more propriospinal axons.
J Spinal Cord Med, 2008 • January 1, 2008
This case report describes a rare instance of postpartum spinal cord injury (SCI) in a 36-year-old woman with HELLP syndrome. The patient presented with acute tetraplegia caused by multiple epidural a...
KEY FINDING: The patient developed tetraplegia due to multiple epidural and subdural hematomas in the cervical and thoracic spinal canal after delivery.