Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,121-5,130 of 5,253 results
Scientific Reports, 2019 • May 13, 2019
This study investigates the role of CRMP2 phosphorylation in axonal regeneration after optic nerve injury using CRMP2 knock-in mice, where CRMP2 phosphorylation at Ser522 is inhibited. The results ind...
KEY FINDING: Inhibition of CRMP2 phosphorylation suppresses microtubule depolymerization after optic nerve injury.
BRAIN, 2015 • April 4, 2015
The study demonstrates that HS3ST2 is overexpressed in the hippocampus of Alzheimer’s disease patients, suggesting its involvement in the disease's pathology. It shows that 3-O-sulphated heparan sulph...
KEY FINDING: HS3ST2 expression is increased in the hippocampus of Alzheimer's disease patients compared to age-matched controls.
Neural Regeneration Research, 2015 • November 1, 2015
The study investigates the effects of apoptosis-related signal transduction pathways following ischemic spinal cord injury, including extracellular signal-regulated kinase (ERK), serine-threonine prot...
KEY FINDING: The expression of phosphorylated Akt (p-Akt) and phosphorylated ERK (p-ERK) increased immediately after reperfusion, peaked at 4 hours (p-Akt) or 2 hours (p-ERK), decreased at 12 hours, and then increased at 24 hours.
J. Clin. Med, 2022 • December 15, 2022
Sensorineural hearing loss is a prevalent condition lacking comprehensive pharmacological treatments due to its complex molecular pathology. Extracellular vesicles (EVs) present a promising therapeuti...
KEY FINDING: Extracellular vesicles (EVs) can modulate a wide range of pathologic and physiologic pathways and can be manufactured under GMP conditions.
The Journal of Neuroscience, 2011 • October 12, 2011
This study identifies a novel signaling mechanism in axonal guidance, where the chemoattractant Netrin-1 and its receptor DCC couple with SNARE proteins (Sytx1 and TI-VAMP) to regulate membrane turnov...
KEY FINDING: The Netrin-1 receptor DCC forms a protein complex with the t-SNARE protein Syntaxin-1 (Sytx1) in a Netrin-1-dependent manner.
Scientific Reports, 2023 • July 6, 2023
This study elucidates the mechanism by which macrophages, after SCI, attract astrocytes, a critical process in glial scar formation. The research demonstrates that macrophage migration dictates the di...
KEY FINDING: Impaired macrophage migration leads to a wider distribution of reactive astrocytes and larger glial scar formation after spinal cord injury.
IEEE Trans Biomed Eng, 2013 • March 1, 2013
Paralysis has huge repercussions for individuals, families, and society, manifesting in various forms due to multiple disorders and affecting multiple body systems, with heterogeneity within patient g...
KEY FINDING: Electrical stimulation can be used to restore latent circuits or act as a neuroprosthetic intervention.
The Journal of Neuroscience, 1999 • September 1, 1999
The study demonstrates that PSA-NCAM1 neural precursors, when transplanted into demyelinated lesions in the adult rat spinal cord, can efficiently remyelinate axons. This remyelination is achieved by ...
KEY FINDING: PSA-NCAM1 neural precursors can efficiently remyelinate demyelinated lesions in the adult rat spinal cord.
Neural Regeneration Research, 2024 • January 31, 2024
This study demonstrates that RUX promotes functional recovery after SCI by enhancing motor function and axon regeneration. RUX restores the expression of EAAT2 in astrocytes, reduces inflammation, and...
KEY FINDING: Ruxolitinib promotes motor function recovery and neuronal survival after spinal cord injury in mice.
Frontiers in Cellular Neuroscience, 2019 • July 24, 2019
This study investigates the pro-neuroregenerative activity of ENDF1, a prenylated flavonoid, on dorsal root ganglion (DRG) neurons in the presence of extracellular matrix (ECM) growth inhibitors. The ...
KEY FINDING: ENDF1 promotes neurite regrowth of DRG neurons despite the presence of inhibitory ECM molecules.