Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,131-5,140 of 5,253 results
JOURNAL OF NEUROTRAUMA, 2010 • December 1, 2010
This study investigates strategies to rescue injured rat cervical motoneurons following C7 ventral root avulsion. The approaches included reimplantation, nerve grafts, and riluzole treatment, both alo...
KEY FINDING: Avulsion without reimplantation resulted in very low numbers of surviving motoneurons.
Cells, 2022 • August 2, 2022
In this review, we discussed fibrotic scar formation in CNS injuries with information covering pathological fibroblasts’ origins and the mechanism of fibroblast activation. We reviewed how a CNS fibrotic ...
KEY FINDING: Meningeal fibroblasts have long been shown to play a role in the fibrotic scar formation in CNS trauma after migrating into the lesion through the torn meninges.
PLoS Biology, 2010 • June 22, 2010
This present study demonstrates that the intracellular levels of NCS1 in adult cortical neurons can be significantly elevated by transduction with a lentiviral vector. Similarly, analogous experiments...
KEY FINDING: NCS1 overexpression in uninjured corticospinal neurons exhibited axonal sprouting across the midline into the CST-denervated side of the spinal cord following unilateral pyramidotomy.
Neurochemical Research, 2025 • November 30, 2024
The study developed a novel slow-release nanoparticle estrogen (SNP-E2) delivery system that provides sustained release of E2 in the injured spinal cord without systemic exposure. Delivery of E2 via S...
KEY FINDING: SNP-E2 delivery reduced inflammation and gliosis, and induced microglial differentiation of M1 to M2 in rats after SCI.
PNAS, 2007 • March 13, 2007
The study identifies pleiotrophin (PTN) as a neurotrophic factor upregulated in denervated distal nerve and muscle. Exogenous PTN enhances axonal regeneration and protects facial motor neurons from tr...
KEY FINDING: PTN mRNA is upregulated in denervated Schwann cells and muscle after axotomy, peaking at 7 days and returning to baseline by 3 months.
Journal of Neuroinflammation, 2011 • August 30, 2011
Successful peripheral axon regeneration is associated with a rapid and efficient inflammatory response that is terminated in due course. Schwann cells and macrophages communicate via cytokine networks...
KEY FINDING: Axon degeneration in the distal nerve instigates subsequent degenerative processes after PNI; however, axon degeneration does not begin immediately.
Journal of the Royal College of Physicians of London, 1994 • March 1, 1994
The review discusses the lack of spontaneous repair in the adult human central nervous system and explores strategies for promoting brain repair. These strategies include understanding developmental p...
KEY FINDING: Growth factors can protect neurons and glia from injury, promoting survival and potentially restoring normal cellular arrangements. Specifically, BDNF protects dopaminergic neurons, and bFGF protects hippocampal neurons from excitotoxic injury.
Neurology, 2019 • March 12, 2019
This study summarizes current and emerging imaging techniques for assessing neuroprotection and repair in multiple sclerosis (MS). It provides a consensus opinion on each technique's utility in clinic...
KEY FINDING: Conventional MRI measures in acute lesions can assess myelin integrity and repair, leveraging routinely collected data, though lacking pathologic specificity and requiring signal normalization.
eLife, 2021 • September 29, 2021
This study performed single-cell transcriptional profiling of mouse DRG in response to peripheral and central axon injuries. The study provides a map of the distinct DRG microenvironment responses to ...
KEY FINDING: Each cell type in the DRG microenvironment responds differently to peripheral (sciatic nerve crush), dorsal root crush, and spinal cord injuries.
J. Vis. Exp., 2012 • February 16, 2012
The spinal cordslice is an ideal recipient tissue for studying NPC ex vivo behaviours, post-transplantation, because the cytoarchitectonic tissue organization is well preserved within these cultures T...
KEY FINDING: NPCs showed highly directed cell migration towards the cathode when exposed to a range of physiological EFs.