Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,201-5,210 of 5,253 results
Molecular Pain, 2006 • August 17, 2006
This study demonstrates that peripheral nerve injury induces changes in the excitability and sodium channel expression in the VPL nucleus of the thalamus. Specifically, the expression of Nav1.3 sodium...
KEY FINDING: Peripheral nerve injury (CCI) leads to increased firing rates of VPL neurons in response to peripheral stimuli.
Spinal Cord Series and Cases, 2017 • October 3, 2017
This survey has addressed the current use, perceived usefulness, and recommendations for modification to the current edition of the ISAFSCI. The survey results revealed the need to further educate clin...
KEY FINDING: Only a small percentage of respondents use the ISAFSCI regularly in their clinical practice.
BMJ Case Rep, 2016 • June 3, 2016
This case report describes a patient with myelomalacia (spinal cord damage) in the posterior funiculus associated with a ventral longitudinal intraspinal fluid collection (VLISFC). The underlying caus...
KEY FINDING: The patient presented with myelomalacia located in the posterior funiculus at C3 in addition to the anterior horn from C2 to C4.
Stem Cell Reports, 2020 • June 9, 2020
The study identifies vascular cell adhesion molecule 1 (VCAM1) as a cell surface marker for a previously unrecognized subpopulation of neural stem cells (NSCs) in the adult mouse hippocampus. VCAM1-ex...
KEY FINDING: VCAM1 is expressed on the cell surface of qNSCs in the adult hippocampus.
Biol Bull, 2011 • August 1, 2011
This paper discusses the use of functional genomics and gene network analysis to study regeneration, focusing on the central nervous system. It proposes using the lamprey as a model system due to its ...
KEY FINDING: Functional genomics can be used to elucidate gene regulatory networks (GRNs) in developing tissues, which, like regeneration, are complex systems, therefore, can also be applied to study the molecular mechanisms underlying the complex functions of regeneration.
Eur J Neurosci, 2012 • July 1, 2012
This study aimed to determine if variations in step training could improve locomotor recovery in spinal cord-injured rats. Rats were trained to step forward, sideward, or backward after spinal cord tr...
KEY FINDING: Rats trained in sideward and backward stepping showed greater step consistency and coordination during forward stepping compared to forward-trained rats.
J Mol Neurosci, 2015 • May 30, 2015
The study aimed to identify reliable markers for avulsion-injured spinal motoneurons, as traditional markers like ChAT are not detectable early after injury. The researchers investigated the expressio...
KEY FINDING: ATF-3 is a marker for avulsion-injured motoneurons. It was rapidly induced and sustained in the nuclei of injured motoneurons.
Exp Neurol, 2010 • May 1, 2010
This study introduces an in vitro model of adult mammalian nerve repair, combining spinal cord slices with peripheral nerve grafts. The model allows for real-time imaging of axon regeneration and prec...
KEY FINDING: Adult nerve grafts remain viable in the co-culture system, maintaining their structure and function, as evidenced by Schwann cell morphology and growth factor expression.
JOURNAL OF NEUROTRAUMA, 2018 • August 1, 2018
This study evaluates the safety and efficacy of rose bengal derivatives for glial scar ablation in a rat model of chronic spinal cord injury. The researchers compared unmodified rose bengal (RB1) with ...
KEY FINDING: Unmodified rose bengal (RB1) was more effective than the hydrocarbon-modified derivative (RB2) in reducing glial scar components while maintaining minimal collateral effects on spared tissue.
Cell Stem Cell, 2016 • January 7, 2016
The study establishes optogenetic control in human PSC-derived spinal motorneurons and demonstrates functional connectivity with human skeletal muscle. The resulting neuromuscular junction can be trig...
KEY FINDING: Optogenetic stimulation produced calcium spikes in myofibers, which could be blocked by vecuronium.