Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,191-5,200 of 5,253 results
Cells, 2021 • April 10, 2021
This study demonstrates that hair-follicle-associated pluripotent (HAP) stem cells can be efficiently differentiated into dopaminergic neurons in vitro. These HAP stem cell-derived dopaminergic neuron...
KEY FINDING: Mouse HAP stem cells can efficiently differentiate into dopaminergic neurons when cultured in neural-induction medium.
Frontiers in Systems Neuroscience, 2015 • February 18, 2015
This review explores the role of rhythm generation circuitry in humans, particularly its relevance to locomotion and rehabilitation after spinal cord or brain injuries. It highlights the significance ...
KEY FINDING: Tonic central and peripheral sensory inputs can activate the spinal CPG circuitry in healthy humans, leading to stepping-like movements.
The Journal of Neuroscience, 2017 • November 8, 2017
This study investigates whether intraspinal chondroitinase ABC (ChABC) can augment plasticity of the corticospinal tract (CST) and improve recovery even during chronic stroke. The results showed that ...
KEY FINDING: Chondroitinase ABC (ChABC) injections into the spinal cord during chronic stroke induced significant sprouting of corticospinal axons originating in the peri-infarct cortex, indicating increased structural plasticity.
Front. Neurosci., 2020 • March 10, 2020
This study used in vivo two-photon microscopy to examine the dynamic changes in cerebral vasculature and red blood cell (RBC) velocities following mild traumatic brain injury (mTBI) in mice. The resul...
KEY FINDING: mTBI induced significant decreases in the diameters and RBC velocities of arterioles and capillaries from 0.5 to 6 hours post-injury, with partial recovery by 1 day.
Neurobiology of Aging, 2014 • February 15, 2014
The study uses quantitative multiparameter mapping (MPM) to identify widespread age-related differences in the microstructure of the human brain. MPM quantifies R1, R2*, MT, and PD*. Significant demye...
KEY FINDING: Significant demyelination occurs primarily in the white matter, with anatomically specific age-related differences in myelination observed.
Frontiers in Neurology, 2022 • May 20, 2022
Spinal Cord Injury (SCI) is a serious condition with limited effective treatments, often resulting in inflammation, apoptosis, autophagy, and oxidative stress. The mTOR signaling pathway plays a key r...
KEY FINDING: Quercetin has antioxidant and anti-inflammatory properties, promotes autophagy, and inhibits apoptosis, making it a potential drug for SCI.
Signal Transduction and Targeted Therapy, 2023 • August 13, 2023
The study demonstrates that tauopathy can trigger Aβ pathology in the primate spinal cord, providing new insight into the pathogenesis and treatment of tauopathy. The researchers found that tauopathy ...
KEY FINDING: Tauopathy resulting from embryonic transgenic Tau expression or stereotaxic brain injection of AAV-Tau selectively promoted the generation of Aβ oligomers in the monkey spinal cord.
Computational and Mathematical Methods in Medicine, 2016 • March 28, 2016
This study presents a mathematical model to investigate axon regeneration around glial scars after spinal cord injury, focusing on the impact of inhibitory factors and scar size. The model, based on S...
KEY FINDING: The level of inhibitory factors on the surface of glial scar significantly impacts axon elongation.
SpringerPlus, 2014 • June 24, 2014
This study aimed to establish a standardized laparoscopic approach for pudendal nerve localization and electrode implantation in pigs. The laparoscopic technique proved feasible, reproducible, and saf...
KEY FINDING: Laparoscopic access to the pudendal nerve was successfully established in all pigs.
Glia, 2017 • December 1, 2017
This study identifies PAR2 as a key regulator of myelin development, resiliency, and regeneration in the central nervous system (CNS). The absence of PAR2 leads to increased myelin production during d...
KEY FINDING: Genetic deletion of PAR2 accelerates myelin production, resulting in higher levels of myelin-related proteins and thicker myelin sheaths.