Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,211-5,220 of 5,253 results
SMALL GTPASES, 2020 • January 1, 2020
Adult CNS axons fail to regenerate after injury due to extrinsic inhibitory factors and a low intrinsic capacity for axon growth, unlike developing neurons. ARF6 and Rab11, small GTPases, regulate pol...
KEY FINDING: ARF6 activation prevents the axonal transport of integrins in Rab11 endosomes in mature CNS axons, restricting them to the somato-dendritic domain.
PLoS ONE, 2015 • July 13, 2015
This study analyzed a large Australian dataset to compare outcomes from in-patient rehabilitation (IPR) in working-aged adults across different groups of long-term neurological conditions. The analysi...
KEY FINDING: All six groups (Stroke, ABI, SCI, GBS, Progressive, CP) showed statistically significant change (p<0.001) between admission and discharge in both motor and cognitive subscales as well as total scores.
J Physiol, 2016 • December 4, 2015
This study investigated the impact of high-thoracic SCI on cerebrovascular structure and function in rats. Seven weeks post-SCI, researchers assessed the middle cerebral artery (MCA) for structural an...
KEY FINDING: Experimental SCI leads to inward cerebrovascular remodeling, increased stiffness, and impaired reactivity of the largest cerebral artery.
Neuroscience, 2014 • December 26, 2014
Plasticity is the basis for behavioral changes, involving neural network shaping and synaptic remodeling. Brain reorganization after CNS lesions plays a role in recovery and rehabilitation but can als...
KEY FINDING: Cortical reorganization after spinal cord injury is species-dependent, with varying degrees and patterns observed in humans, non-human primates, and rats.
Dev Dyn, 2010 • November 1, 2010
This paper presents a method for visualizing 3D relationships in intact and regenerating adult newt spinal cords using fluorescent probes and confocal microscopy. The method involves fixation, decalci...
KEY FINDING: PLP with 0.5% PFA fixative provided the best streptavidin probe penetration while preserving cellular morphology.
Explor Neuroprotective Ther., 2024 • January 1, 2024
This review describes the roles of S1P and LPA receptors in neurodegeneration and potential neuroprotection. Fingolimod, an S1P receptor agonist, is clinically used for multiple sclerosis and shows ne...
KEY FINDING: Fingolimod, an S1P receptor agonist, is clinically effective in multiple sclerosis and shows neuroprotective effects in various neuropathologies, including stroke and Alzheimer’s disease.
Frontiers in Neuroanatomy, 2023 • March 21, 2023
This study quantified structural changes in capillary morphology and microstructure from the acute to chronic stages of SCI, providing insights into the microvascular pathology and potential targets f...
KEY FINDING: Acute microvascular disruption was evident post-SCI, particularly at the injury epicentre, spreading three spinal segments rostrally and caudally.
Cellular & Molecular Immunology, 2020 • October 27, 2020
This study investigates the effects of the small-molecule TPN10456 on Th17 cell differentiation and its potential therapeutic role in multiple sclerosis (MS). The research demonstrates that TPN10456 ...
KEY FINDING: TPN10456 inhibits Th17 cell differentiation in a dose-dependent manner. The addition of TPN10456 resulted in a dose-dependent reduction in the frequency of IL-17A-producing cells.
Sensors, 2015 • February 16, 2015
This study presents a real-time pressure-monitoring system for fastening systems in powered robotic exoskeletons, aimed at preventing skin injuries by monitoring pressure exerted by the straps. The sy...
KEY FINDING: The pressure monitoring system successfully recorded pressure dynamics in the fastening straps of a lower-limb exoskeleton for both able-bodied and SCI subjects.
The Journal of Spinal Cord Medicine, 2016 • January 1, 2016
This case report describes an unusual presentation of seronegative NMO, where the patient's initial symptom of relapse was acute respiratory failure requiring mechanical ventilation. The patient's cer...
KEY FINDING: The patient presented with acute respiratory failure as the primary symptom of NMO relapse, which is an atypical presentation.