Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 71-80 of 5,253 results
Frontiers in Rehabilitation Sciences, 2023 • April 19, 2023
This perspective paper highlights the limitations of current spinal stimulation therapies that primarily focus on locomotor rehabilitation after spinal cord injury (SCI), while neglecting other critic...
KEY FINDING: Underlying differences in neural network behavior exist among individuals with similar motor impairments after SCI. These differences are often masked by population-level analyses, highlighting the need for personalized approaches.
medRxiv preprint, 2023 • December 23, 2023
This study measured genital arousal in response to neuromodulation in women and found that acute DGNS, but not TNS, can increase subjective arousal. The effect of stimulation on genital arousal is inc...
KEY FINDING: Subjective arousal increased significantly from before to after stimulation in DGNS study sessions across all women.
Cells, 2023 • May 6, 2023
This study investigates a multi-faceted therapeutic approach for spinal cord injury (SCI), combining nanomedicines (NMeds) loaded with triiodothyronine (T3), systemic ibuprofen, and mouse nerve growth...
KEY FINDING: The "combo" therapy reduced M1 microglia activation and glutamate levels in the short term, indicating a strong anti-inflammatory effect.
Int. J. Mol. Sci., 2023 • May 2, 2023
This review discusses the role of cAMP-specific PDE inhibition in modulating neuroinflammation and promoting neuroregeneration following SCI in rodent models. The review highlights the potential of PD...
KEY FINDING: Inhibition of cAMP-specific PDEs, particularly PDE4, PDE7, and PDE8, shows potential in managing neuroinflammation and promoting regeneration in the central nervous system after SCI.
J. Clin. Med., 2023 • April 27, 2023
As healthcare professionals, we have discussed evidence to help substantiate the importance of the use of electrical stimulation activities for individuals with SCI. These activities can play an impor...
KEY FINDING: NMES and FES activities provided positive results on muscle mass after eight to sixteen weeks of training. Atkins and Bickel [21] reported increases in muscle volume that range from 20–72% with an average increase of 26% among NMES and FES studies.
Frontiers in Neuroscience, 2023 • April 5, 2023
This study investigated the effect of epidural spinal cord stimulation (ESCS) on sexual function and distress in women with spinal cord injury (SCI). Three females with chronic, complete SCI received ...
KEY FINDING: There was a 3.2-point (13.2%) mean increase in total FSFI from baseline to post-intervention, with improvements in desire, arousal, orgasm and satisfaction.
Curr. Issues Mol. Biol., 2023 • April 7, 2023
The study examined the effects of whole-body vibration (WBV) and passive flexion-extension (PFE) therapy on neurotrophin-3 (NT-3) expression and microglia/macrophage reaction after spinal cord injury (...
KEY FINDING: WBV therapy, initiated 14 days post-SCI, resulted in the best overall functional recovery.
Biomedicines, 2023 • March 27, 2023
This study investigates the use of rTMS and peripheral electrotherapy, both separately and in conjunction with kinesiotherapy, for managing incomplete spinal cord injury (iSCI). The research aims to i...
KEY FINDING: Peripheral electrotherapy, especially when combined with kinesiotherapy, showed a higher percentage of neurophysiological improvement than rTMS alone.
Journal of NeuroEngineering and Rehabilitation, 2023 • May 2, 2023
This article provides a conceptual overview of functional electrical stimulation (FES), a novel neuromodulation-based treatment modality that can be potentially used in the treatment of disorders of d...
KEY FINDING: FES may attenuate the negative interoceptive bias associated with MDD by enhancing positive facial feedback.
Neurology, 2023 • July 11, 2023
This study reviewed institutional experience with SCInf and evaluated predictors of outcome, dividing the cohort into spontaneous and periprocedural cases. Spontaneous SCInf tended to affect a single ...
KEY FINDING: Patients with spontaneous SCInf showed significantly better admission AIS, fewer multilevel SCInf, shorter hospital stay, and better AIS and ambulatory status on long-term follow-up.