Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 81-90 of 5,253 results
Experimental Biology and Medicine, 2023 • April 1, 2023
This study demonstrates that ALA increases GABAAR-mediated inhibitory activity in the BLA and CA1 pyramidal neurons 24 h after injection in young adult Sprague-Dawley male rats. The study showed that ...
KEY FINDING: Administration of ALA increased the charge transfer of inhibitory postsynaptic potential currents mediated by GABAA receptors in pyramidal neurons in the BLA and CA1 compared to vehicle animals.
DIGITAL HEALTH, 2023 • May 2, 2023
The study utilizes a Kinect-based motion analysis system to objectively evaluate bradykinesia in Parkinson's disease (PD) patients, comparing them to healthy controls (HC). Kinematic features derived ...
KEY FINDING: Significant correlations were found between kinematic features measured by the Kinect system and clinical scales used to assess Parkinson's disease.
Top Spinal Cord Inj Rehabil, 2023 • July 1, 2023
This study aimed to gather input from people living with SCI regarding their priorities, preferences, and concerns related to spinal cord stimulation (SCS). The survey results indicated varying priori...
KEY FINDING: Individuals with tetraplegia prioritized fine motor skills and upper body function, while those with paraplegia prioritized standing, walking, and bowel function.
Nature, 2023 • June 1, 2023
The study introduces a brain–spine interface (BSI) that restores communication between the brain and spinal cord in an individual with chronic tetraplegia, enabling natural standing and walking. The B...
KEY FINDING: The BSI enabled volitional control over muscle activity, restoring more natural and adaptive control of standing and walking.
Top Spinal Cord Inj Rehabil, 2023 • July 1, 2023
This scoping review synthesizes evidence on epidural SCS for improving motor control, neurological recovery, and voiding in individuals with chronic SCI. Epidural SCS, originally for chronic pain, has...
KEY FINDING: Epidural SCS can lead to variable improvements in volitional motor function in individuals with SCI.
Top Spinal Cord Inj Rehabil, 2023 • July 1, 2023
Spinal cord electrical stimulation is being explored to improve autonomic function in individuals with spinal cord injuries (SCI), particularly to address orthostatic hypotension. The commentary quest...
KEY FINDING: Spinal cord stimulation may improve blood pressure in SCI patients with orthostatic hypotension by stimulating vascular sympathetic outflow.
Children, 2023 • May 5, 2023
Sarcopenia is immediate and profound following spinal cord injury-related paralysis. The diminished muscle mass negatively affects the development and metabolism of the growing child and is associated...
KEY FINDING: Muscle mass correlates with functional outcomes in children with paralysis related to spinal cord-related neurologic deficits.
Biomedicines, 2023 • April 26, 2023
This review examines the distribution of electric fields in the spinal cord during tsDCS, as predicted by MRI-based models, comparing this information with clinical findings to optimize tsDCS protocol...
KEY FINDING: tsDCS-induced electric fields are generally safe and can induce both immediate and long-lasting changes in the spinal cord.
Int. J. Mol. Sci., 2023 • May 11, 2023
Endurance training prior to SCI has a beneficial effect on the activation of signaling pathways responsible for survival, neuroplasticity, and neuroregeneration. In the pretrained SCI group, the functi...
KEY FINDING: Endurance training alone increased the gene expression and protein level of immature CNP-ase oligodendrocytes (~16%) at Th10, and caused rearrangements in neurotrophic regulation of inhibitory GABA/glycinergic neurons at the Th10 and L2 levels.
Bioelectronic Medicine, 2023 • May 16, 2023
This review summarizes the effects of five types of neuromodulation (FES, ES, FNS, TSCS and EES) on improving trunk and sitting functions in people with SCI, discussing limitations and future research...
KEY FINDING: Neuromodulation techniques, including FES, ES, FNS, TSCS, and EES, have shown potential in improving trunk stability and sitting functions in individuals with SCI.