Browse the latest research summaries in the field of neuroplasticity for spinal cord injury patients and caregivers.
Showing 101-110 of 159 results
Exp Neurol, 2016 • March 1, 2016
This study characterized the dendritic morphology and neurotransmitter phenotype of thoracic descending propriospinal neurons (dPSNs) after spinal cord transection and GDNF treatment in adult rats. Th...
KEY FINDING: dPSNs in animals without injury had dendrites mainly distributed in a top-bottom direction. Injury caused the dendrites to retract in this direction and extend sideways.
Front. Neural Circuits, 2018 • March 13, 2018
This study investigates the plasticity of the serotonergic system in turtles after spinal cord injury (SCI). It was hypothesized that SCI may trigger homeostatic changes in serotonergic innervation. T...
KEY FINDING: Spinal cord injury (SCI) in turtles leads to an initial reduction in serotonergic innervation followed by an increase in serotonergic cells caudal to the lesion site after 30 days.
Brain, 2018 • June 14, 2018
This study introduces a novel immune-evasive gene switch (dox-i-ChABC) that enables regulated delivery of ChABC in the injured mammalian spinal cord, providing an experimental tool to control delivery...
KEY FINDING: A novel immune-evasive gene switch (dox-i-ChABC) enables regulated delivery of ChABC in the injured mammalian spinal cord.
Neural Regen Res, 2019 • January 1, 2019
This review examines the differences in neuroplasticity following spinal cord injury (SCI) among animal models and humans, highlighting variations in sensorimotor pathways and recovery rates. It discu...
KEY FINDING: Rats regain weight-bearing abilities without interventions two weeks post-injury, unlike humans.
JOURNAL OF NEUROTRAUMA, 2019 • June 15, 2019
This study investigates the potential of chondroitinase ABC (ChABC) to enhance plasticity and recover respiratory motor function after severe midcervical contusion injury in rats. The key finding is t...
KEY FINDING: ChABC treatment at chronic stages post-cervical contusion injury leads to recovery of normal activity in the ipsilateral hemidiaphragm.
The Journal of Neuroscience, 2020 • October 21, 2020
This study investigates the functional relevance of reticulospinal fiber growth after cervical hemisection, focusing on local rewiring of axotomized projections and compensatory outgrowth of spared ax...
KEY FINDING: Locally rewired and compensatory NRG fibers are responsible for different aspects of recovered forelimb and hindlimb functions, including stability, strength, coordination, speed, and timing.
Neural Plasticity, 2021 • February 8, 2021
This pilot study investigated the impact of the rubber hand illusion (RHI) and repetitive transcranial magnetic stimulation (rTMS) on brain connectivity in healthy participants and a patient with spin...
KEY FINDING: There is no difference in connectivity between sham and real TBS or in the effectiveness of RHI.
Brain Res, 2007 • May 29, 2007
This study demonstrates that bone marrow stromal cell (BMSC) treatment following a stroke enhances axonal sprouting and rewiring of the corticospinal (CST) and corticorubral (CRT) tracts. The research...
KEY FINDING: BMSC treatment significantly increased axonal restructuring in the de-afferented red nucleus and denervated spinal motoneurons after stroke.
Stroke, 2008 • September 1, 2008
The study demonstrated that corticospinal tract fibers originating from the contralesional motor cortex sprout into the denervated spinal cord after stroke and bone marrow stromal cells treatment. BMS...
KEY FINDING: Stroke reduced the stimulation threshold evoking ipsilateral forelimb movement.
Neurotherapeutics, 2011 • April 1, 2011
Motor, sensory, and autonomic functions can spontaneously return after spinal cord injury. The mechanisms are summarized under the term plasticity. Plasticity includes alterations in spared neuronal c...
KEY FINDING: Plasticity occurs throughout the neuraxis after spinal cord injury, involving alterations in neuronal circuits, axon sprouting, and synaptic rearrangements.