Browse the latest research summaries in the field of neuroplasticity for spinal cord injury patients and caregivers.
Showing 111-120 of 159 results
JOURNAL OF NEUROTRAUMA, 2010 • March 1, 2010
The study examined molecular changes in the cervical spinal cord of rhesus monkeys after traumatic brain injury (TBI), focusing on long-term effects up to 12 months post-lesion. Key findings include i...
KEY FINDING: There were significant increases in MHC-II and ERK1/2 immunoreactivity in the lateral corticospinal tract (LCST) of the cervical spinal cord up to 12 months post-lesion, indicating long-term microglial activation.
Brain Res, 2010 • April 6, 2010
This study investigates how diffuse traumatic brain injury (TBI) affects the activation and reorganization of the whisker-barrel circuit in rats. The researchers hypothesized that the extent of functi...
KEY FINDING: Whisker somatosensory regions of the cortex and thalamus maintained cellular composition as visualized by Nissl stain.
Exp Neurol, 2012 • May 1, 2012
This review highlights experimental strategies to restore respiratory function after spinal cord injury (SCI), focusing on the innate plasticity and capacity for adaptation in the respiratory system a...
KEY FINDING: Pharmacological treatments, such as theophylline, can partially restore function to the paralyzed hemidiaphragm by increasing respiratory drive.
Journal of Neuroinflammation, 2013 • January 14, 2013
This study challenges previous in vitro findings by demonstrating that IL-1β exerts detrimental effects on axon plasticity, lesion development, and gliosis after spinal cord injury (SCI) in mice. The ...
KEY FINDING: Local application of recombinant IL-1β worsened the neurological outcome after SCI in mice.
Neural Regen Res, 2014 • March 1, 2014
The field of spinal cord injury research has evolved, with some trends losing momentum and new approaches emerging. A balanced treatment approach for spinal cord injury is needed, including neuroprote...
KEY FINDING: Treatments aimed at promoting regeneration have been found to promote sprouting of spared and injured nerve cells, further supporting the shift towards studying neuroplasticity.
Journal of NeuroEngineering and Rehabilitation, 2009 • February 17, 2009
Noninvasive brain stimulation (NBS) is being investigated for neurological conditions, with the understanding that it can modulate neuroplasticity. Plasticity is considered crucial for functional reco...
KEY FINDING: Neuroplasticity, involving both neuronal and non-neuronal mechanisms, plays a significant role in brain function, with synaptic transmission being a key site for plasticity.
AGING (Albany NY), 2016 • October 15, 2016
The Plasticity Related Gene family covers five, brain‐specific, transmembrane proteins (PRG1‐5, also termed LPPR1‐5) that operate in neuronal plasticity during development, aging and brain trauma. Com...
KEY FINDING: PRG3 induces the formation of filopodia and promotes axonal growth.
The Journal of Spinal Cord Medicine, 2017 • May 1, 2017
This pilot study investigated whether pretreatment with ibuprofen could enhance the effects of acute intermittent hypoxia (AIH) on lower extremity motor function in individuals with chronic incomplete...
KEY FINDING: AIH significantly increased maximal voluntary plantar flexion torque (leg strength) at 30 and 60 minutes post-AIH compared to baseline in individuals with chronic incomplete SCI.
PLoS Biology, 2015 • June 30, 2015
The study used simultaneous brain and cervical cord fMRI to investigate spinal cord plasticity during motor sequence learning. Results showed learning-related modulation of activity in the C6–C8 spina...
KEY FINDING: Greater BOLD activity was found within the C6–C8 levels of the ipsilateral spinal cord during a complex motor sequence learning task compared to a simple one.
Neural Plasticity, 2020 • April 1, 2020
This pilot study investigated the effects of combining the rubber hand illusion (RHI) with high-frequency repetitive transcranial magnetic stimulation (rTMS) on tactile sensation in healthy subjects a...
KEY FINDING: The rubber hand illusion (RHI) itself had a strong effect on participants' sense of touch and body ownership.