Neuroplasticity Research

KEY FINDING: Combining rehabilitation with stem cell-based therapies can improve upper extremity function in cervical SCI, especially when using neuromodulation to activate neural circuits below the injury level.

KEY FINDING: ApoE4 mice showed worse locomotor function and coordination after SCI compared to ApoE3 mice, as measured by the Basso Mouse Scale (BMS) and ladder rung walk test (LRWT).

KEY FINDING: Spinal cord injury enables plasticity by down-regulating the Cl− co-transporter KCC2, which reduces GABAergic inhibition, enabling learning but also fueling over-excitation and nociceptive sensitization.

KEY FINDING: Neuroplasticity is a key driver of recovery from neurological injury, and understanding how interventions modulate the nervous system can lead to complete neurological healing.

KEY FINDING: Combined AIH and TST produce a synergistic effect on motor plasticity, resulting in greater functional benefits than either treatment alone.

KEY FINDING: The number of long propriospinal neurons (PSNs) with axons extending below the lesion was significantly and permanently decreased after injury.

KEY FINDING: Serum BDNF significantly increased at high exercise intensities compared to moderate intensities and post-exercise.

KEY FINDING: Both 2 and 4 weeks of ch'abc treatment significantly increased the number of rubrospinal tract (RuST) neurons with axons below the lesion.

KEY FINDING: Operant conditioning protocols can induce specific changes (up- or down-regulation) in targeted spinal reflexes, as demonstrated in various animal models and humans.

KEY FINDING: Short-term IH administration enhances respiratory function in humans with SCI.