Browse the latest research summaries in the field of neuroplasticity for spinal cord injury patients and caregivers.
Showing 41-50 of 159 results
Exp Neurol, 2021 • January 1, 2021
This study investigated the effects of combining PCMS with AIH on spinal plasticity in humans with chronic incomplete SCI. The hypothesis was that PCMS combined with AIH would boost spinal plasticity ...
KEY FINDING: PCMS combined with AIH resulted in a significantly greater increase in MEP amplitude compared to PCMS with sham AIH, suggesting enhanced corticospinal excitability.
Frontiers in Cellular Neuroscience, 2020 • October 14, 2020
Neural stimulation modulates the depolarization of neurons, thereby triggering activity-associated mechanisms of neuronal plasticity. New research has uncovered genetic mechanisms that govern the expr...
KEY FINDING: Patterns of depolarization in neurons are shown to be important mediators of genetic expression patterns and molecular responses.
JOURNAL OF NEUROTRAUMA, 2021 • May 1, 2021
This study compared the effects of prolonged daily acute intermittent hypoxia (dAIH) versus chronic intermittent hypoxia (CIH) on phrenic motor outcomes in rats with chronic cervical spinal cord injur...
KEY FINDING: Daily acute intermittent hypoxia (dAIH) enhanced phrenic long-term facilitation (pLTF) bilaterally in rats with chronic cervical spinal cord injury (cSCI) compared to those exposed to normoxia.
Neural Plasticity, 2021 • February 2, 2021
This study used VBM and graph theoretical network analyses to investigate alterations in GMV and GMV-based SCNs in complete thoracic SCI patients within one postinjury year, and partial correlation an...
KEY FINDING: SCI patients showed reduced gray matter volume in the left middle frontal cortex, right superior orbital frontal cortex (OFC), and left inferior OFC.
International Journal of Molecular Sciences, 2021 • May 4, 2021
Exercise stands out as a key therapy for spinal cord injury (SCI), offering benefits beyond peripheral health by activating neural pathways and alleviating central nervous system disorders. Exercise r...
KEY FINDING: Exercise can modify the injury environment, promoting axonal sprouting of local spinal networks and remaining descending axons.
Physical Therapy Research, 2021 • April 1, 2021
This study investigated anatomical changes in the brain following chronic complete traumatic thoracic spinal cord injury (ThSCI) using voxel-based morphometry (VBM). Decreases in volume were noted in ...
KEY FINDING: Decreased gray matter volume was observed in brain areas associated with motor and somatosensory functions, including the right paracentral lobule (PCL), left dorsal premotor cortex, and left superior parietal lobule (SPL).
Biology, 2021 • September 28, 2021
Neuroplasticity is a robust mechanism by which the central nervous system attempts to adapt to a structural or chemical disruption of functional connections between neurons. Following damage to nervou...
KEY FINDING: Spontaneous plasticity of the spared components of the CST is a compensatory mechanism underlying forelimb motor recovery, as opposed to the restoration and/or regeneration of the damaged motor tract.
Frontiers in Rehabilitation Sciences, 2022 • July 22, 2022
This study examined the feasibility of operant down-conditioning of the soleus H-reflex in individuals after stroke with chronic spastic hemiparesis. Twelve participants completed 6 baseline and 30 co...
KEY FINDING: Operant down-conditioning can decrease the soleus H-reflex size in some people after stroke, specifically in 50% of the participants in this study.
Neurospine, 2022 • September 1, 2022
This review examines the effects of acute physical interventions on pathophysiology and recovery after spinal cord injury (SCI), focusing on interventions initiated within the first 8 days post-injury...
KEY FINDING: Treadmill training initiated very early (within 3 days post-injury) may worsen autonomic function, inflammation, and locomotor outcomes.
Biomedicines, 2022 • October 13, 2022
The article reviews current interventions for spinal cord injury (SCI) treatment, focusing on rehabilitation phases and emphasizing a neuroplasticity-based multimodal approach. It highlights the integ...
KEY FINDING: Biomolecular approaches alone have modest outcomes in SCI treatment.