Browse the latest research summaries in the field of oncology for spinal cord injury patients and caregivers.
Showing 91-100 of 144 results
JOURNAL OF PALLIATIVE MEDICINE, 2010 • May 1, 2010
This retrospective study assessed the frequency of advance directives and DNR orders in 88 patients with MSCC requiring rehabilitation consultation. The study found low rates of advance care planning ...
KEY FINDING: Only 23% of patients had a living will, 31% had health care proxies, and 11% had either out-of-hospital DNR order and=or dictated DNR note.
Proc. Natl. Acad. Sci. USA, 1996 • October 1, 1996
Mechanical injury to the adult mammalian spinal cord results in permanent loss of structural integrity at the lesion site and of the brain-controlled function distal to the lesion. After x-ray therapy...
KEY FINDING: X-irradiation of sectioned adult rat spinal cord resulted in restitution of structural continuity and regrowth of severed corticospinal axons across and deep into the distal stump.
Journal of Medical Case Reports, 2024 • November 23, 2024
This case report describes a rare instance of spinal schwannoma presenting with intraspinal hematoma in a 53-year-old female. The patient experienced sudden lower limb pain, necessitating emergency su...
KEY FINDING: The patient presented with a T12 schwannoma accompanied by an intratumoral hematoma, experiencing sudden and unbearable pain in the lower limbs.
Spinal Cord Series and Cases, 2018 • April 8, 2018
This case report highlights the increasing occurrence of conditions like soft tissue sarcomas in the aging population of individuals with spinal cord injuries (SCI). It details the successful treatmen...
KEY FINDING: This case report is the first documented instance of a soft tissue sarcoma (STS) in the limb of a patient with long-term paraplegia due to traumatic spinal cord injury (SCI).
Radiation Oncology, 2007 • June 30, 2007
The review summarizes experimental strategies for preventing and treating radiation-induced CNS toxicity, including neurocognitive decline and radiation necrosis, highlighting the importance of tailor...
KEY FINDING: Early intervention with agents like amifostine and growth factors (IGF-1, FGF-2) shows preliminary evidence of modulating the radiation response in the CNS and increasing long-term radiation tolerance.
Hereditas, 2023 • April 3, 2023
The study investigates the mechanism by which γ-T3, a form of vitamin E, regulates gastric cancer cells, focusing on its impact on gene expression and signaling pathways. RNA-seq analysis of γ-T3-trea...
KEY FINDING: γ-T3 treatment alters the expression of mRNA and ncRNA in gastric cancer cells, indicating a broad impact on cellular functions.
J Spinal Cord Med, 2007 • January 1, 2007
The paper presents two cases of spinal cord injury caused by epidural B-cell lymphoma. Both patients presented with sensory deficits greater than motor deficits and gait disorder. Both patients achiev...
KEY FINDING: B-cell lymphoma can present as an epidural tumor causing spinal cord compression and injury.
Eur Spine J, 2003 • November 19, 2002
This case report describes a 48-year-old man with an intramedullary schwannoma extending from the conus medullaris to T11, causing bilateral lower extremity weakness. Gross total resection of the tumo...
KEY FINDING: Schwann cells can indeed invade the central nervous system, as demonstrated by the presence of an intramedullary schwannoma within the conus medullaris.
Cells, 2023 • June 21, 2023
This study provides a detailed characterization of the galanin (GAL) system in the human bile duct and perihilar cholangiocarcinoma (pCCA), examining the expression of GAL and its receptors (GAL1–3-R)...
KEY FINDING: GAL and GAL1-R were expressed in various bile duct cell types, GAL2-R was slightly expressed, and GAL3-R specifically in cholangiocytes and capillaries.
International Journal of Molecular Sciences, 2022 • January 5, 2022
The study evaluates the effectiveness of spliceosome-mediated RNA trans-splicing (SMaRT) as a targeted cancer therapy approach for epidermolysis bullosa-associated skin cancer (RDEB-SCC). The results ...
KEY FINDING: RTM44, an RNA trans-splicing molecule, can effectively target the cancer gene Ct-SLCO1B3 in RDEB-SCC cells, leading to the expression of a fusion product at the mRNA and protein level.