Browse the latest research summaries in the field of oncology for spinal cord injury patients and caregivers.
Showing 11-20 of 144 results
CANCER BIOLOGY & THERAPY, 2024 • December 3, 2024
This study investigates the efficacy of dinaciclib, a Cdk inhibitor, in treating biliary tract cancer (BTC) using in vitro models. The findings indicate that dinaciclib reduces cell viability, ATP lev...
KEY FINDING: Dinaciclib reduces cell viability, ATP levels, and proliferation rates in BTC cells.
The Journal of Spinal Cord Medicine, 2022 • March 1, 2022
The study compared demographic data, injury characteristics, medical comorbidities, and functional outcomes of neoplastic and traumatic SCI patients in an inpatient rehabilitation program. Neoplastic ...
KEY FINDING: Neoplastic SCI patients were significantly older than traumatic SCI patients.
The Journal of Spinal Cord Medicine, 2022 • May 1, 2022
This study compared CRC mortality in SCI patients to CRC mortality in the general population to determine if any disparities exist. The study found no significant difference in overall CRC mortality b...
KEY FINDING: The overall standardized mortality ratio (SMR) for CRC mortality in the SCI population was 1.11 (95% CI [0.94, 1.31]), indicating no statistically significant increase compared to the general population.
Spinal Cord, 2021 • June 17, 2021
This study, based on data from 135 SCI/D patients with bladder cancer, confirms that bladder cancer tends to occur at a younger age and with more advanced tumors in SCI/D patients. The study found no ...
KEY FINDING: No significant differences were found in tumor characteristics when stratified by bladder management, SCI/D severity, and ASIA classification.
Spinal Cord Series and Cases, 2021 • July 15, 2021
This retrospective study investigated survival, rehabilitation needs, and discharge destinations of patients undergoing surgery for metastatic spinal cord compression (MSCC). The study revealed a disc...
KEY FINDING: The probability of survival after 90- and 180-days post-surgery were 78% and 57%, respectively.
Cell Death Discovery, 2021 • May 14, 2021
This study investigates the role of CtBP and Snail in tumor invasion using Drosophila as a model organism. The researchers found that both CtBP and Snail are required for tumor growth and invasion tri...
KEY FINDING: Depletion of CtBP or Snail (Sna) suppressed RasV12/lgl-/--triggered tumor growth and invasion, and disrupted cell polarity-induced invasive cell migration in Drosophila.
BMC Neurol, 2021 • June 29, 2021
This case report describes an 80-year-old man who presented to the ER with confusion and walking difficulties and was found to have spinal cord compression caused by a plasmacytoma. The patient's CSF ...
KEY FINDING: Spinal cord compression by plasmacytoma can lead to abnormal CSF levels of several known pathology markers for Alzheimer’s disease and neuronal damage.
Neuro-Oncology, 2022 • January 1, 2022
This scoping review highlights the key features of 174 clinical studies on spinal neoplasms registered from 2000 to 2020. Clinical trials are more focused on metastatic tumors than primary tumors, ref...
KEY FINDING: Most registered clinical studies were interventional and led by single institutions, mainly in North America and Europe.
Archives of Rehabilitation Research and Clinical Translation, 2021 • January 1, 2021
This case series highlights the importance of the rehabilitation team in the continuum of care for patients undergoing resection of primary melanocytomas of the spinal cord. Presenting symptoms can be...
KEY FINDING: Primary spinal melanocytomas, though rare, may be more common than reported due to their insidious nature and non-specific symptoms, potentially leading to delayed or missed diagnoses.
Medicina, 2022 • March 1, 2022
This study evaluated the effect of minimally invasive spine stabilization (MISt) in 51 patients with metastatic spinal tumors. MISt is a minimally invasive fixation procedure that temporarily stabilize...
KEY FINDING: MISt can benefit patients who are ineligible for conventional, highly invasive surgery.