Browse the latest research summaries in the field of orthopedics for spinal cord injury patients and caregivers.
Showing 231-240 of 352 results
Neurospine, 2023 • June 1, 2023
This study assessed the relationship between static and dynamic factors and the severity of cervical myelopathy in OPLL patients. The study found that minimal SAC, Cobb angle, total ROM, and local ROM...
KEY FINDING: Minimal space available for the spinal cord (SAC), C2–7 Cobb angle, total range of motion (ROM), and local ROM were identified as independent predictors of myelopathy in OPLL patients.
Biomedicines, 2023 • July 18, 2023
The study compares cytokine profiles in serum and tissues of patients with and without OPLL to identify potential biomarkers and understand the mechanisms behind ossification. The research identifies ...
KEY FINDING: Serum leptin levels are significantly higher in OPLL patients compared to non-OPLL patients, suggesting it may serve as a disease marker.
Advanced Science, 2023 • October 23, 2023
This study investigates the use of hypoxic preconditioning to improve the therapeutic function of MSC-derived sEVs for treating IVD degeneration and chronic lower back pain. HP-sEVs were found to alle...
KEY FINDING: Hypoxic preconditioning enhances the therapeutic function of MSC-derived sEVs for IVD regeneration.
Frontiers in Physiology, 2023 • October 11, 2023
This study investigates the role of mechanical stimulation in heterotopic ossification (HOTL) using a mouse model with Enpp1 gene deficiency. The mice were subjected to spinal immobilization and tread...
KEY FINDING: Spinal immobilization effectively restricts the flexion and extension of cervical and thoracic vertebrae in mice, delaying spinal ligament ossification and reducing chronic secondary spinal cord injury.
Neurospine, 2023 • December 1, 2023
The study aimed to determine which indicator—lumbar vertebral Hounsfield units (HU), vertebral bone quality (VBQ), or bone mineral density (BMD)—is most effective in predicting thoracolumbar fragility...
KEY FINDING: Lumbar vertebral HU exhibited a positive correlation with BMD (p < 0.01).
Cells, 2024 • January 15, 2024
This editorial summarizes a special issue focused on the molecular mechanisms of intervertebral disc (IVD) degeneration and regeneration, highlighting new treatment strategies. The issue includes six ...
KEY FINDING: Hyperbaric oxygen (HBO) intervention may protect against IVD degeneration via mir-107/Wnt3a-β-catenin signaling.
Journal of Orthopaedic Surgery and Research, 2024 • January 1, 2024
This study investigates the therapeutic potential of exosomes derived from umbilical cord mesenchymal stem cells (UC-MSCs) in treating spinal cord injury (SCI). The findings suggest that UC-MSC-derive...
KEY FINDING: UC-MSC-derived exosomes improved motor ability in SCI rats compared to those without exosome treatment.
European Journal of Medical Research, 2024 • March 11, 2024
The study investigated COMP and ADAMTS7 as potential biomarkers for IVDD. Both animal and human studies showed that COMP and ADAMTS7 expression increased in tissues and serum during IVDD progression....
KEY FINDING: Serum COMP (sCOMP) and serum ADAMTS7 (sADAMTS7) levels increased in a time-dependent manner following IVD damage in the rabbit model.
Frontiers in Endocrinology, 2024 • May 10, 2024
This study uses Mendelian randomization (MR) to explore the causal relationships between hormonal and reproductive factors (ANM, AAM, LMC, AFB, AFS, ALB) and the prevalence of low back pain (LBP). The...
KEY FINDING: AAM (OR=0.784, 95% CI: 0.689-0.891; p=3.53E-04), AFB (OR=0.558, 95% CI: 0.436-0.715; p=8.97E-06), ALB (OR=0.396, 95% CI: 0.226-0.692; p=0.002), and AFS (OR=0.602, 95% CI: 0.518-0.700; p=3.47E-10) were associated with a decreased risk of LBP.
Journal of Bone and Mineral Metabolism, 2024 • August 30, 2024
The study constructs Enpp1flox/flox/EIIa-Cre mice to model spinal ectopic ossification, providing a basis for future studies on HOTL. These mice exhibit ossified spines and Achilles tendon abnormaliti...
KEY FINDING: Enpp1 deficiency leads to progressive heterotopic ossification (HO), especially in the spine and Achilles tendons, and is associated with progressive degeneration of the knees.