Browse the latest research summaries in the field of orthopedics for spinal cord injury patients and caregivers.
Showing 221-230 of 352 results
Trials, 2022 • November 3, 2022
This study protocol outlines a comprehensive cohort trial comparing full-endoscopic and microsurgical techniques for lumbar disc herniation treatment. The study includes a randomized and a non-randomi...
KEY FINDING: The study aims to compare the results of lumbar discectomies using the full-endoscopic technique via the interlaminar and trans-foraminal access with those of the conventional microsurgical technique, particularly with regard to iatrogenic muscle trauma and patient-related outcome measures.
Frontiers in Bioengineering and Biotechnology, 2022 • December 16, 2022
This study found that HA treatment induces mitophagy in NPCs, preventing ROS overproduction and mitochondrial impairment, which subsequently inhibits cell apoptosis, senescence and ECM degradation via...
KEY FINDING: Hyaluronic acid (HA) can protect mitochondrial function through activation of mitophagy in nucleus pulposus cells (NPCs).
Am J Transl Res, 2022 • December 30, 2022
This study investigates the role of m6A RNA methylation modification in the immune microenvironment of ligamentum flavum hypertrophy (LFH). It utilizes bioinformatics analysis of the GSE113212 dataset...
KEY FINDING: Identified 1259 differentially expressed genes in LFH samples compared to normal samples, with significant differences observed in METTL16, PCIF1, and FTO, which are related to m6A modification.
Int. J. Environ. Res. Public Health, 2023 • January 4, 2023
This retrospective study analyzed data from 159 CRPS patients to identify epidemiological and clinical factors associated with the condition. The study population consisted mainly of women with an ave...
KEY FINDING: The study confirmed a higher occurrence of CRPS in females. The hand and wrist were the most commonly affected areas, followed by the ankle and foot.
Int. J. Mol. Sci., 2023 • January 12, 2023
This study investigates the potential of using chondrocytes isolated from loose bodies (LB-CH) as a cell source for autologous chondrocyte implantation (ACI) to reduce donor site morbidity. LB-CH were...
KEY FINDING: LB-CH exhibited comparable viability and proliferation rates to control cells during long-term expansion, with no ultimate cell cycle arrest observed within 12 passages.
Medicina, 2023 • January 5, 2023
This study aimed to verify PRP injection safety and efficacy in LBP patients with Modic type 1. As a preliminary experiment, two LBP cases with Modic type 1 are presented. There were no adverse events ...
KEY FINDING: There were no adverse events in physical condition, laboratory data, or lumbar X-rays after injection, suggesting that PRP intradiscal injection is safe.
Cells, 2023 • February 3, 2023
This study explored the therapeutic potential of injecting a mixture of rapidly expanding clone (REC) cells and ultra-purified alginate (UPAL) non-gelling solution into intervertebral discs (IVDs) to ...
KEY FINDING: The injection of REC and UPAL mixture suppressed the expression of TNF-α, IL-6, and TrkA in rat models.
World Journal of Orthopedics, 2023 • February 18, 2023
The study investigates the effects of human neural stem cells-secretome (HNSCs-secretome) on spinal cord injury (SCI) regeneration in a rat model. Results indicate that HNSCs-secretome improves locomo...
KEY FINDING: HNSCs-secretome significantly improved locomotor recovery, as measured by BBB scores, in rats with SCI.
BMC Musculoskeletal Disorders, 2023 • March 28, 2023
This study investigated the feasibility of minimally invasive plate osteosynthesis (MIPO) for treating distal humeral fractures, including both extra-articular and intra-articular types. The researche...
KEY FINDING: Reduction and plate fixation of all distal humeral fractures (8 cadaveric) with and without osteotomy was feasible.
JOR Spine, 2023 • April 1, 2023
This study investigates the role of DLX5 in the progression of OPLL, a condition characterized by the ossification of spinal ligaments. The findings indicate that DLX5 expression is upregulated in OPL...
KEY FINDING: DLX5 is highly expressed in OPLL cells compared to non-OPLL cells, both in vitro and in vivo.