Browse the latest research summaries in the field of orthopedics for spinal cord injury patients and caregivers.
Showing 241-250 of 352 results
Quant Imaging Med Surg, 2024 • April 10, 2024
The study validated an AI-based MAC algorithm for improving image quality in low-dose CT scans following percutaneous vertebroplasty (PVP). The AI-MAC algorithm demonstrated superior performance compa...
KEY FINDING: AI-MAC demonstrated no significant difference compared to reference images in CT attenuation, image noise, signal-to-noise ratios (SNRs), and contrast-to-noise ratio (CNR).
Cureus, 2025 • February 20, 2025
The microglial response to SCI is dynamic and multifaceted, involving a complex interplay of pro-inflammatory and anti-inflammatory processes that influence the outcome of the injury. The role of NF-k...
KEY FINDING: NF-kB signaling greatly influences how microglia respond to SCI, impacting inflammation, tissue damage, and the potential for healing.
Frontiers in Physiology, 2025 • March 19, 2025
This study investigates the impact of spinal hypermobility on the development of ossification of the posterior longitudinal ligaments (OPLL) using an in vivo mouse model. The researchers induced hyper...
KEY FINDING: Spinal hypermobility accelerates the progression of ossification in mice with heterotopic ossification of spinal ligaments.
The Journal of Spinal Cord Medicine, 2015 • January 1, 2015
The study aimed to assess the differences in functional activity, perceived health, and depressive symptoms between individuals with traumatic paraplegia with and without shoulder pain. The results in...
KEY FINDING: Shoulder pain was prevalent in 30% of patients with traumatic paraplegia.
Acta Orthopaedica et Traumatologica Turcica, 2017 • April 25, 2017
This study aimed to evaluate the effect of PRP on spinal cord injury repair in a rat model. The results showed that motor recovery was significantly better in rats treated with PRP 24 hours after inju...
KEY FINDING: Motor recovery was significantly better in rats treated with PRP 24 hours after injury compared to the control group.
International Journal of Molecular Sciences, 2018 • January 9, 2018
This study investigated the effects of intraarticular administration of MSCs in a rat model of shoulder arthritis induced by MIA. The findings indicate that MSCs can inhibit central sensitization of p...
KEY FINDING: Intraarticular injection of MSCs decreased the expression of CGRP in the spinal dorsal horn, indicating a suppression of central sensitization of pain.
Therapeutics and Clinical Risk Management, 2018 • January 1, 2018
This prospective safety study evaluated the impact of BMP-7 on cytokine expression in non-union therapy by comparing IGF-1, PDGF-AB, and TGF-β levels in patients treated with ABG alone versus ABG with...
KEY FINDING: IGF-1 levels were generally higher in the ABG-only group (G2) compared to the BMP-7 group (G1), but the overall course of expression was similar.
Trials, 2018 • May 10, 2018
This study is a randomized controlled trial designed to evaluate the non-inferiority of bioactive glass (BaG) compared to autologous bone graft (ABG) in treating tibial and femoral non-unions using th...
KEY FINDING: The primary endpoint of the study is union achieved 1 year after surgery.
International Journal of Molecular Sciences, 2018 • June 5, 2018
This study compares the effects of IGF-1 and BMP-7 on osteogenic differentiation of human mesenchymal stem cells (MSCs) from reaming debris (RMSC) and iliac crest bone marrow (BMSC) in vitro. The resu...
KEY FINDING: BMSC showed a more sensitive reaction towards stimulation with IGF-1, leading to a significantly higher degree of osteogenic differentiation compared to stimulation with BMP-7.
Medical Devices: Evidence and Research, 2018 • January 1, 2018
The study introduces a novel electroceutical device that delivers percutaneous direct current (DC) stimulation to treat severe neurological pain and soft tissue injuries. The device mimics and modulat...
KEY FINDING: Percutaneous DC stimulation significantly reduced pain and attack frequency in a patient with chronic cluster headaches, leading to complete remission for over 3 years.