Orthopedics Research

KEY FINDING: The combination of ceftriaxone and ADMSCs resulted in significantly lower levels of TNF-α and IL-6 in both circulatory and spinal cord fluid compared to ceftriaxone or ADMSCs alone, indicating a stronger anti-inflammatory effect.

KEY FINDING: Adult CIM patients often have more severe clinical manifestations, including brainstem and cranial nerve compression, leading to scoliosis deformities being overlooked.

KEY FINDING: Identified 75 differentially expressed aging-circadian rhythm related genes between normal and KOA groups, primarily enriched in the circadian rhythm pathway.

KEY FINDING: Approximately half of DISH-related spinal fractures were accompanied by neurological symptoms, and 41% of the patients exhibited paralysis.

KEY FINDING: UBE group had shorter operative time compared to the PECD group (65.6 ± 17.6 vs. 85.1 ± 24.2 min, p < 0.001), but the former had longer incision length than the latter (2.4 ± 0.4 cm vs. 1.3 ± 0.4 cm, p < 0.001).

KEY FINDING: The patient experienced transient improvements post-cervical decompression but later developed delirium, worsening right-sided weakness, and bilateral foot drop.

KEY FINDING: CTGF was found to be the most effective growth factor for inducing the differentiation of UCMSCs into tendon cells, leading to changes in cell morphology and increased expression of tendon-specific proteins.

KEY FINDING: A 55-year-old man with a stable L1 burst fracture developed delayed neurological deficits two weeks after sustaining a fall, despite no evidence of intrinsic or extrinsic spinal cord abnormalities on MRI.

KEY FINDING: Intraoperative monitoring was used in approximately 60% of scoliosis surgeries with reported complications.

KEY FINDING: The incidence of voice complications after ACDF varied widely, from 0.3 to 27%, likely due to differing measurement methods.