Browse the latest research summaries in the field of orthopedics for spinal cord injury patients and caregivers.
Showing 311-320 of 352 results
European Journal of Trauma and Emergency Surgery, 2025 • January 11, 2025
This study investigates the use of periosteal flaps (PF) to enhance bone healing in non-unions, comparing a vascularized (pedicled) PF to a ligated PF and a control group in a rat femur model. The res...
KEY FINDING: The pedicled periosteal flap (PF) group showed a significantly higher bone volume compared to the other groups after 10 weeks.
Stem Cell Research & Therapy, 2024 • May 7, 2024
This study aimed to evaluate potential synergistic effects of hUC-MSC-sEVs with rhBMP-2 in promoting regeneration of a metaphyseal femoral defect in an osteoporotic rat model. The results demonstrated...
KEY FINDING: The co-application of hUC-MSC-sEVs can improve the efficacy of rhBMP-2 to promote the regeneration of osteoporotic bone defects.
Bioactive Materials, 2023 • January 1, 2023
This review provides an overview of the role of EVs in OA, focusing on the pathogenesis, diagnosis, and treatment, while considering the associated challenges and limitations. The review summarizes th...
KEY FINDING: EVs play a significant role in OA pathogenesis by influencing inflammation, metabolism, and cellular senescence within joint tissues.
MJAFI, 2001 • January 1, 2001
This study analyzes the initial experience of stabilization of thoracolumbar spine fractures using Harrington system, Universal spine system and Pedicle screw and plate fixation. The commonest locatio...
KEY FINDING: Neurological improvement occurred in 65% of surgically treated patients with incomplete cord injury.
Aging and Disease, 2022 • April 1, 2022
This study investigates the role of CB2R in intervertebral disc degeneration (IVDD) by examining its effects on nucleus pulposus cell (NPC) senescence both in vitro and in vivo. The study found that C...
KEY FINDING: CB2R expression is decreased in degenerated nucleus pulposus (NP) tissues from both human IVDD patients and rat acupuncture IVDD models, while the expression of p16INK4a increased.
J Spinal Cord Med, 2006 • January 1, 2006
This case report describes a 19-year-old man with a complete cervical spinal cord injury who developed bilateral hip effusions. The etiology of hip effusion in paralyzed patients is likely multifactor...
KEY FINDING: Aseptic hip joint effusion can occur in patients with tetraplegia (paralysis of all four limbs).
PRS Global Open, 2021 • June 22, 2021
Targeted muscle reinnervation and regenerative peripheral nerve interfaces are increasingly utilized strategies to mitigate phantom and residual limb pain in amputees. In this case report, the authors...
KEY FINDING: The patient reported a decrease in pain score from eight to four upon activation of the nerve stimulator postoperatively.
Scientific Reports, 2025 • January 9, 2025
The study aimed to analyze cervical sagittal alignment changes following growing rod treatment in early-onset scoliosis (EOS) and identify risk factors for cervical imbalance using machine learning. T...
KEY FINDING: Growing rod surgery significantly affects cervical sagittal alignment in EOS patients.
Dose-Response: An International Journal, 2020 • October 1, 2020
The study demonstrates that miR-152 expression is downregulated in the cartilage tissues of patients with osteoarthritis and in chondrocytes exposed to IL-1b. This downregulation suggests a potential ...
KEY FINDING: miR-152 expression is significantly lower in cartilage tissue from OA patients and in chondrocytes treated with IL-1b, suggesting its involvement in OA progression.
Nature Communications, 2022 • May 6, 2022
The study demonstrates that miR-17 has dual functions: maintaining cartilage homeostasis and protecting against OA. Decreased miR-17 expression in OA chondrocytes contributes to disease progression. I...
KEY FINDING: MiR-17 expression is decreased in osteoarthritic chondrocytes, and its deficiency contributes to OA progression.