Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 611-620 of 639 results
J Venom Anim Toxins incl Trop Dis, 2020 • May 20, 2020
The study investigates the neuroprotective and immunomodulatory effects of dimethyl fumarate (DMF) combined with a heterologous fibrin sealant (FS) following ventral root avulsion (VRA) and reimplanta...
KEY FINDING: DMF treatment at 15 mg/kg preserved motoneurons and synapses and decreased astrogliosis and microglial reactions, downregulating pro-inflammatory gene transcripts.
Toxins, 2020 • July 2, 2020
This review summarizes recent experimental findings on the potential efficacy of BoNTs in favoring nerve regeneration after traumatic injury in the peripheral nervous system, such as the injury of per...
KEY FINDING: BoNT/A has shown potential in promoting axonal regeneration after peripheral nerve injury (PNI), which was observed from experimental and clinical data.
ACS Chem. Neurosci., 2020 • July 15, 2020
This study investigates the neurotropic activity and safety of a methylene-cycloalkylacetate (MCA) derivative, HU-MCA-13, as a potential drug for treating polyneuropathies. The research evaluates the ...
KEY FINDING: HU-MCA-13 induced neurite outgrowth in PC12 dopaminergic cell cultures, dorsal root ganglion (DRG) sensory neurons and adult rat spinal cord primary cultures.
PLoS ONE, 2020 • July 17, 2020
The study introduces SUN13837, a novel small-molecule compound that mimics the beneficial effects of bFGF without its proliferative side effects. In vitro experiments demonstrated that SUN13837 promot...
KEY FINDING: SUN13837 promotes neurite outgrowth in primary cultures of rat hippocampal neurons, similar to bFGF.
Toxins, 2020 • July 31, 2020
The study investigates the therapeutic potential of Botulinum neurotoxin type A (BoNT/A) in treating spinal cord injury (SCI) in mice. BoNT/A is known for its ability to block SNARE complex formation ...
KEY FINDING: BoNT/A induces a complete recovery of muscle and motor function in a murine model of severe spinal cord injury (SCI) when administered spinally within one hour from spinal trauma.
NeuroReport, 2020 • January 1, 2020
This study investigates the protective effects of Tricholoma matsutake polysaccharides (TMP) on spinal cord injuries (SCIs) both in vitro and in vivo. The results showed that TMP promotes neuronal pro...
KEY FINDING: TMP promoted neurite growth and inhibited the production of TNFα, IL-6, and NF-kappa B in cells treated with hydrogen peroxide.
Neural Regeneration Research, 2021 • February 1, 2021
Hydrogel-based drug delivery strategies offer unique opportunities to locally deliver drugs to the injured spinal cord with sufficient dose and duration, while avoiding deleterious side effects associ...
KEY FINDING: Hydrogel pore size can be varied to control drug release, with larger pore sizes leading to faster drug release.
Dose-Response: An International Journal, 2020 • July 1, 2020
The study successfully developed a biofabricated nano-cerium oxide loaded PCL polymer with RVL, characterizing the nanomaterial through various analytical techniques. The CeO2-PCL/RVL bionanomaterials...
KEY FINDING: Nano CeO2 particles assembled onto PCL/RVL were successfully synthesized using a biocompatible ionic liquid.
Neural Regeneration Research, 2021 • March 1, 2021
This study investigates the antidepressant effects of solid lipid nanoparticles loaded with curcumin and dexanabinol in a mouse model of major depressive disorder. The results demonstrate that the nan...
KEY FINDING: Solid lipid nanoparticles loaded with curcumin and dexanabinol increased the mRNA and protein expression levels of mature neuronal markers (NeuN, MAP2, Tuj1) in wild-type mice.
Neurology, 2020 • December 15, 2020
This observational study examined the association between the timing of gabapentinoid administration and motor recovery after spinal cord injury. The study found that early administration of gabapenti...
KEY FINDING: Early administration (within 30 days) of gabapentinoids after spinal cord injury is associated with improved motor recovery.