Browse the latest research summaries in the field of physiology for spinal cord injury patients and caregivers.
Showing 201-210 of 292 results
Journal of Sports Science and Medicine, 2005 • September 1, 2005
This study evaluated the effect of early FES-CE intervention on skeletal muscle morphology in traumatic SCI patients 4–6 weeks after injury, comparing them to SCI controls and uninjured controls. The ...
KEY FINDING: Without intervention, muscle fiber cross sectional area (CSAf ) decreased 38% and 65% at 6 and 19 weeks post-SCI, respectively.
PLoS ONE, 2014 • March 20, 2014
The study aimed to quantify different muscle activation patterns in the lower limbs of children with CP using an instrumented assessment. Fifty-four children with CP were included, and their muscle ac...
KEY FINDING: Muscle activation patterns were found to be both muscle- and subject-specific, indicating variability in how spasticity manifests in different muscles and individuals.
Indian Journal of Orthopaedics, 2014 • March 1, 2014
This prospective longitudinal study evaluated body composition changes in 95 patients with acute SCI using DEXA during the first year post-injury. The study found a marked decrease in BMC and LBM with...
KEY FINDING: There was a significant decrease in BMC (P < 0.05) and LBM (P < 0.05) and increase in total body fat mass (TBFM) and percentage fat at infra‑lesional sites.
Journal of Visualized Experiments, 2015 • September 23, 2015
This study presents an in vitro model using organotypic spinal cord co-cultures on MEAs to investigate functional regeneration after spinal cord injury. The model allows for the study of propriospinal...
KEY FINDING: Cultures lesioned at a young age (7 - 9 DIV) displayed a high amount of synchronized activity 2-3 weeks after lesion, indicating a greater capacity for regeneration.
Dev Biol, 2015 • December 1, 2015
This study investigates the response of ependymoglial cells to spinal cord injury in axolotls, focusing on the role of membrane potential dynamics in regeneration. The research demonstrates that spina...
KEY FINDING: Spinal cord injury induces a rapid and dynamic change in the resting membrane potential of ependymoglial cells in axolotls.
Neural Regen Res, 2021 • July 1, 2021
The study systematically analyzed clinical neurological functions, combined with examination of SEP and MEP, ranging from gross to fine motor skills in a rat model of SCI. Rats with severe SCI showed ...
KEY FINDING: Somatosensory and motor-evoked potential amplitudes decreased and latencies increased after spinal cord contusion injury.
Exp Neurol, 2021 • April 1, 2021
This study investigated serotonergic reinnervation of respiratory motor nuclei (phrenic and intercostal) following cervical spinal hemisection (C2Hx) in rats, and the impact of different intermittent ...
KEY FINDING: Spontaneous serotonergic reinnervation of the phrenic and intercostal motor nuclei is substantial 12 weeks post-C2Hx.
Translational Psychiatry, 2021 • April 19, 2021
This study investigates the acute effects of therapeutic and overdose concentrations of lithium on human iPSC-derived cortical neurons using MEA and patch-clamp techniques. The findings reveal that th...
KEY FINDING: Therapeutic concentrations of lithium increase neuronal excitability and network activity in human iPSC-derived cortical neurons.
Exp Neurol, 2021 • December 1, 2021
This study demonstrates that phrenic motor neurons (PMNs) survive after cervical spinal cord hemisection (C2Hx) in rats, challenging previous findings suggesting substantial motor neuron death caudal ...
KEY FINDING: C2Hx had no detectable impact on phrenic motor neuron survival with either subacute (2-weeks) or chronic (8-weeks) spinal injury.
Frontiers in Cellular Neuroscience, 2022 • May 19, 2022
This corrigendum addresses errors found in Figure 5 of the original article concerning ATPIF1's role in sevoflurane-induced microglial inflammatory responses. The errors involved incorrect labeling in ...
KEY FINDING: Correction of identification errors of notes (E–J) in the legend for Figure 5.