Browse the latest research summaries in the field of physiology for spinal cord injury patients and caregivers.
Showing 211-220 of 292 results
bioRxiv, 2023 • February 27, 2023
This study investigates the role of DOCK3 in skeletal muscle using a muscle-specific knockout mouse model. The researchers found that loss of DOCK3 in skeletal muscle leads to impaired muscle regenera...
KEY FINDING: Dock3 mKO mice presented with significant hyperglycemia and increased fat mass, indicating a metabolic role in the maintenance of skeletal muscle health.
Int. J. Mol. Sci., 2023 • March 1, 2023
This study investigates the consequences of axotomy on the function of principal neurons of the primary motor cortex layer V (M1LV) in a rat model of SCI. Transection of the dorsal corticospinal tract...
KEY FINDING: Axotomized M1LV neurons became excessively depolarized after SCI, meaning their resting membrane potential was higher than normal.
J. Pers. Med., 2023 • February 28, 2023
This study evaluated the usefulness of motor potentials evoked transvertebrally at lumbar levels in assessing peroneal nerve regeneration in rats after experimental repair. Recordings were performed 2...
KEY FINDING: MEP and ENG stimulations both resulted in evoked potentials, with larger amplitude values following the application of magnetic pulses.
BRAIN, 2025 • September 20, 2024
This study explores the role of LGI1 in regulating pain sensitivity by genetically ablating LGI1 in specific neuron populations of transgenic mice, revealing its high expression in DRG and spinal cord...
KEY FINDING: LGI1 is highly expressed in dorsal root ganglion (DRG) and spinal cord dorsal horn neurons in both mouse and human.
European Journal of Pain, 2025 • January 1, 2025
This translational study examined the interaction between descending inhibitory controls and spinal amplification in pain modulation, using parallel human and rat models. The study found that spinal a...
KEY FINDING: In humans, concurrent application of a noxious conditioning stimulus did not affect pain ratings to a single pinprick stimulus, repetitive stimulation or the wind-up ratio.
Frontiers in Neuroscience, 2025 • January 17, 2025
The study investigates the impact of epidural ULF neuromodulation on thalamic neuron responses to peripheral sensory stimulation and pathological thalamic activity in a neuropathic pain model. Results...
KEY FINDING: ULF current can acutely and reversibly interrupt signaling between sensory afferent fibers and relay neurons of the thalamus.
Neural Regeneration Research, 2015 • February 1, 2015
The capacity of the central nervous system to reorganize its circuits after injury is key to developing rehabilitative strategies in persons with SCI. Electrophysiological studies may shed light on th...
KEY FINDING: After SCI, the early spinal reflex component decreases in amplitude, while a late component emerges and becomes dominant, correlating with walking capacity impairment.
Neural Regeneration Research, 2019 • June 1, 2019
This case study examined motor output reorganization in a patient with unihemispheric cortical atrophy due to Rasmussen encephalitis, focusing on ipsilateral corticospinal pathways using transcranial ...
KEY FINDING: The patient with Rasmussen encephalitis showed higher median amplitudes of ipsilateral motor evoked potentials (MEPs) in the first dorsal interosseous and wrist extensors muscles compared to healthy controls.
Scientific Reports, 2017 • November 1, 2017
This study aimed to evaluate the feasibility and reliability of standardized motor evoked potential (MEP) recording and analysis in neonatal lambs. The researchers developed an algorithm for MEP quant...
KEY FINDING: MEPs could be easily recorded in neonatal lambs using transcranial motor cortex stimulation.
Journal of Visualized Experiments, 2018 • January 30, 2018
This article describes a surgical and measurement protocol for assessing lower urinary tract function in awake rats, using implanted catheters and electrodes to simultaneously monitor the urinary blad...
KEY FINDING: The success rate for the surgical procedure and maintaining the implanted devices intact is approximately 80%.