Browse the latest research summaries in the field of physiology for spinal cord injury patients and caregivers.
Showing 61-70 of 292 results
Nature Communications, 2020 • February 21, 2020
Denervation of skeletal muscles leads to atrophy, marked by cellular changes like increased plasma membrane permeability and accelerated protein catabolism. The study aimed to identify factors prevent...
KEY FINDING: Acetylcholine (ACh) and its analogs repress the expression of connexin43 and connexin45 hemichannels, which are associated with muscle atrophy.
Clin Auton Res, 2021 • April 1, 2021
The study defines differences in heart rate and blood pressure variability (HRV/BPV) after spinal cord injury (SCI) compared with uninjured controls, and determines if variabilities are impacted by wh...
KEY FINDING: Individuals with SCI exhibited significantly lower LF and HF HRV, as well as LF BPV, compared to uninjured controls.
Biomedical Journal, 2020 • February 26, 2020
The study used novel human neurophysiologic models to investigate whether the mechanism of rate-sensitive H-reflex depression lies in the pre-synaptic or post-synaptic locus in humans. Results from the...
KEY FINDING: Testing MEPs were not diminished in healthy subjects with or without typical rate-sensitive H-reflex depression, or in subjects with sensory-impaired SCI.
Exp Neurol, 2020 • November 1, 2020
The study aimed to understand mechanisms giving rise to residual pLTF following moderate AIH in rats with carotid denervation, hypothesizing that carotid denervation enables greater hypotension during...
KEY FINDING: Carotid denervation leads to more severe hypoxia-induced hypotension compared to sham rats.
Respir Physiol Neurobiol, 2020 • November 1, 2020
This study investigated whether combining high-frequency epidural stimulation (HF-EDS) with pharmacological disinhibition of spinal circuits could improve breathing after complete high cervical spinal...
KEY FINDING: Combining high-frequency epidural stimulation (HF-EDS) with GABA and glycine receptor antagonists (GABAzine and strychnine) significantly increased phrenic motor output compared to HF-EDS alone.
Indian Journal of Orthopaedics, 2020 • April 27, 2020
This study investigated the relationship between neurological deficit and subsequent recovery in acute spinal cord injury (SCI) patients using ASIA score and electrodiagnostic studies. The neurologica...
KEY FINDING: Neurological recovery was highly significant at 6 months based on ASIA scores.
J Neural Eng., 2020 • January 8, 2020
The study examined the effects of spinal cord injury (SCI) on cortically-evoked spinal spiking activity in rats by delivering intracortical microstimulation (ICMS) to the hindlimb motor cortex and rec...
KEY FINDING: In healthy rats, electrical stimulation of the motor cortex evoked reliable spike activity in the spinal cord at short latencies (10-12 ms) and longer latencies (20-60 ms).
Physiological Reports, 2020 • January 1, 2020
This study challenges the conventional method of predicting blood pressure instability after spinal cord injury (SCI) based solely on the neurological classification of SCI. It highlights that individ...
KEY FINDING: Orthostatic hypotension occurred within each level and AIS classification of spinal cord injury, indicating it's not solely predictable by injury severity.
Journal of Rehabilitation Medicine, 2021 • December 4, 2020
Evidence of discomplete spinal cord injury can be demonstrated using standard neurophysiological techniques in a substantial subset of individuals with clinically complete spinal cord injury. This st...
KEY FINDING: Strong neurophysiological evidence of discomplete spinal cord injury was found in 17% (4/23) of participants.
Journal of Multidisciplinary Healthcare, 2020 • January 1, 2020
The study aimed to determine the effect of a 52-week gait training program with an exoskeletal body-powered gait orthosis on the body composition of paraplegics. The gait training program had a positi...
KEY FINDING: The exercise group showed no significant changes in weight, fat-free mass, lean body mass, and percent fat mass after the 52-week program.