Browse the latest research summaries in the field of physiology for spinal cord injury patients and caregivers.
Showing 71-80 of 292 results
Neuromodulation, 2021 • September 1, 2021
The study describes the post hoc clinical and neurophysiological assessment of five patients, three of whom were nonresponders in a neuromodulation study aimed at evoking motor response in motor compl...
KEY FINDING: Nonresponders presented with a complete absence of spasticity and absence of leg reflexes.
Top Spinal Cord Inj Rehabil, 2021 • January 1, 2021
The study compares body composition assessment techniques in individuals with SCI to the 4-compartment (4C) model, the criterion standard for measuring body fat. A regression equation incorporating ag...
KEY FINDING: A regression equation using age, sex, weight, and abdominal skinfold thickness can estimate body fat with reasonable accuracy in SCI patients.
Top Spinal Cord Inj Rehabil, 2021 • January 1, 2021
Cardiometabolic disorders are a leading cause of mortality in persons with SCI, and visceral adipose tissue (VAT) plays a significant role. Factors like age, level of injury, and sex influence VAT dis...
KEY FINDING: Level of injury, age, and time since injury influence visceral adipose tissue (VAT) distribution, but the effect of the level of injury may be influenced by aging and time since injury.
Front. Neural Circuits, 2021 • March 23, 2021
This study investigates the role of CaV1.3 channels in SCI-induced hyperexcitability and the therapeutic potential of CPT, a selective CaV1.3 channel inhibitor, using a mouse model of chronic SCI. The...
KEY FINDING: Chronic SCI mice exhibit hyperexcitability in the spinal motor system, demonstrated by enhanced root reflexes compared to acute SCI mice.
Nutrients, 2023 • January 16, 2023
This study investigated the prevalence of sarcopenic obesity and factors influencing body composition in persons with spinal cord injury (SCI) in Japan. The study found that sarcopenia, obesity, and s...
KEY FINDING: Sarcopenia, obesity, and sarcopenic obesity were prevalent in 76%, 85%, and 64% of patients, respectively.
bioRxiv preprint, 2023 • January 7, 2023
We investigated the role of genetics, age and sex on AIHH-induced respiratory motor plasticity of both cortical (presumably volitional) diaphragm MEPs and brainstem automatic (P0.1) neural pathways in...
KEY FINDING: AIHH-induced changes in diaphragm MEP amplitudes were lower in individuals heterozygous for APOE4 (i.e., APOE3/4) allele versus other APOE genotypes (p=0.048).
Nature Communications, 2023 • January 27, 2023
This study explores segmental strength recovery in upper limb muscles after cervical SCI, identifying factors predictive of recovery. Findings indicate a proximal-to-distal gradient in strength recove...
KEY FINDING: Distal muscles of the upper limb show limited and delayed strength recovery compared to proximal muscles after cervical SCI.
IEEE J Biomed Health Inform., 2023 • March 1, 2023
This study introduces a novel CMAP scan analysis method using staircase function fitting to extract MUNE and other physiological information. The staircase fitting model was validated using simulated ...
KEY FINDING: The staircase function fitting provides an appropriate approach to CMAP scan processing, yielding MUNE and other useful parameters for examination of motor unit loss and muscle fiber reinnervation.
J Comp Neurol, 2020 • June 15, 2020
This study investigated the molecular and histologic responses to spinal cord injury (SCI) in spiny mice (Acomys cahirinus) compared to C57BL/6 mice (Mus). Gene array and RT-qPCR results showed that s...
KEY FINDING: Spiny mice showed increased expression of genes related to neurogenesis and regeneration after spinal cord injury compared to C57BL/6 mice.
Curr Phys Med Rehabil Rep., 2020 • September 1, 2020
Preliminary findings detailed in this review affirm that breathing mild episodes of oxygen-deprived air appears to be a safe and effective therapeutic primer to enhance motor function (i.e., walking) ...
KEY FINDING: Repetitive AIH is a safe and efficacious treatment to enhance strength, walking speed and endurance, as well as, dynamic balance in persons with chronic, incomplete SCI.