Browse the latest research summaries in the field of regenerative medicine & stem cells for spinal cord injury patients and caregivers.
Showing 241-250 of 2,317 results
Cellular and Molecular Neurobiology, 2006 • July 29, 2006
This study investigates the therapeutic potential of human mesenchymal stem cells (hMSCs) for spinal cord injury (SCI) in rats. hMSCs were intravenously injected into rats seven days after SCI, and fu...
KEY FINDING: Transplanted rats showed statistically significant improvement in locomotor function at 21 and 28 days after spinal cord injury compared to the control group.
Phil. Trans. R. Soc. B, 2006 • July 31, 2006
CNS injuries have limited repair capabilities, but functional recovery is observed, which is variable. Neurite growth and new circuit formation require reactivation of developmental mechanisms, suppre...
KEY FINDING: Inactivation of Nogo-A promotes axonal regeneration and improved behavioral recovery after spinal cord injury.
Oncotarget, 2017 • April 27, 2017
The study identifies TRIM32 as a novel essential positive factor modulating axonal regeneration and the recovery of motor function following SCI. TRIM32 deficiency results in impaired axonal regenerat...
KEY FINDING: TRIM32 expression is upregulated in astrocytes and microglia following spinal cord injury.
Neural Regeneration Research, 2017 • April 1, 2017
Paralysis following spinal cord injury (SCI) is due to failure of axonal regeneration. It has been suggested that the small GTPase RhoA is an intracellular convergence point for signaling by these ext...
KEY FINDING: RhoA knockdown promotes true axon regeneration through the lesion site after SCI in lampreys.
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2017 • January 1, 2017
This study investigates the potential of erythropoietin (EPO) to enhance the therapeutic effects of bone marrow mesenchymal stem cells (BMSCs) in treating spinal cord injuries (SCI) in rats. The resul...
KEY FINDING: EPO enhances the recruitment of BMSCs to sites of SCI, leading to increased BMSC presence at the injury site.
Exp Neurol, 2008 • February 1, 2008
Spinal cord and brain injuries initiate intricate responses in the CNS aimed at tissue repair. However, these attempts are often thwarted by inflammatory cell activation, reactive astrogliosis, and in...
KEY FINDING: Glial scars are not merely physical barriers but sources of inhibitory molecules that prevent successful regeneration after CNS injury.
The Journal of Neuroscience, 2007 • October 31, 2007
This symposium summarizes scientific bases for current clinical trials aimed at improving functions after SCI. After primary and secondary damage, endogenous processes may foster or hinder axonal reco...
KEY FINDING: Function-blocking antibodies recognizing Nogo-A induce enhanced regenerative sprouting from injured fibers, long-distance regeneration of subpopulations of fibers, and enhanced compensatory fiber growth from non-injured fibers and tracts.
CNS Neurosci Ther., 2017 • May 29, 2017
This study investigates the use of polyethylene glycol (PEG) to treat spinal paralysis in rats with complete spinal cord transections. Rats treated with PEG showed significant motor recovery compared ...
KEY FINDING: PEG treatment led to recovered ambulation in rats with complete spinal cord transection, as measured by BBB scores.
Neural Regeneration Research, 2017 • May 1, 2017
This meta-analysis evaluated the effectiveness and safety of stem cell transplantation for spinal cord injury (SCI) by analyzing data from ten randomized controlled trials. The findings suggest that s...
KEY FINDING: Stem cell transplantation significantly increased lower limb light touch and pinprick scores compared to rehabilitation therapy.
Exp Neurol, 2008 • June 1, 2008
This study investigates the effect of human adult bone marrow-derived somatic cells (hABM-SC) on stroke recovery in rats. hABM-SC treatment led to improved forelimb function on a skilled motor task, i...
KEY FINDING: hABM-SC therapy after stroke in rats led to significant functional recovery in a skilled forelimb task.