Browse the latest research summaries in the field of regenerative medicine & stem cells for spinal cord injury patients and caregivers.
Showing 251-260 of 2,317 results
Brain, 2008 • August 8, 2008
This clinical trial evaluated the safety and feasibility of autologous olfactory ensheathing cell (OEC) transplantation in patients with complete thoracic paraplegia. The study followed six transplant...
KEY FINDING: The transplantation of autologous olfactory ensheathing cells into the injured spinal cord was found to be feasible and safe for up to 3 years post-implantation.
J Spinal Cord Med, 2008 • January 1, 2008
Successful treatment for spinal cord injury may involve strategies combining neuroprotection, axonal regeneration promotion, and rehabilitation. The most efficacious strategy for the acute complete tr...
KEY FINDING: Combining SCs, OECs, and chondroitinase administration improved locomotion in rats with complete spinal cord transection, leading to increased myelinated axons and serotonergic axons.
BMC Neuroscience, 2009 • April 20, 2009
This study aimed to evaluate the effect of electro-acupuncture (EA) on the survival and differentiation of bone marrow mesenchymal stem cell (MSC) transplantation, axonal regeneration, and functional ...
KEY FINDING: The combination of MSC transplantation and EA treatment significantly increased cAMP and NT-3 levels in the injured spinal cord compared to MSC transplantation or EA treatment alone.
Exp Neurol, 2010 • April 1, 2010
This study investigated the impact of functional electrical stimulation (FES) on cell regeneration in rats with spinal cord injuries (SCI). The research found that FES significantly increased cell bir...
KEY FINDING: FES significantly increased cell birth in the lumbar spinal cord of rats with spinal cord injuries, with an 82-86% increase observed in the injured ‘cell birth’ subgroup.
BMC Neuroscience, 2010 • September 16, 2010
The study investigated the effects of hMSC transplantation on neurogenic bladder and locomotor function recovery in rats with spinal cord injury, also examining the relationship with endogenous neurot...
KEY FINDING: hMSC transplantation reduced ED1 positive macrophages (inflammatory response) in the injured spinal cord compared to control groups.
Cell Mol Neurobiol, 2011 • December 14, 2010
The study investigated the optimal location and timing for neural stem cell (NSC) transplantation in rats with transected spinal cords to improve neurological function. NSC transplantation into spinal...
KEY FINDING: NSC transplantation in the spinal cords rostral to the transection site at the subacute stage (7 days post operation) resulted in significant improvement in hindlimb locomotor functions.
Surgical Neurology International, 2010 • December 25, 2010
This review article discusses the potential of stem cell transplantation for spinal cord regeneration, highlighting the limitations of current management options for SCI and the underlying mechanisms ...
KEY FINDING: Olfactory ensheathing cells (OECs) appear to be the most promising stem cell type for spinal cord regeneration due to their supportive role in axonal regeneration.
Cell Mol Neurobiol, 2011 • January 22, 2011
The study cloned rat TLX cDNA and demonstrated that ectopic expression of TLX enhanced DMSC cell growth and shifts differentiation of DMSCs into neuronal rather than astrocytic phenotypes in vitro. TL...
KEY FINDING: TLX promotes the proliferation of DMSCs. TLX/DMSCs showed enhanced proliferation compared to parental DMSCs.
Exp Neurol, 2011 • May 1, 2011
This study provides evidence that olfactory ensheathing glia (OEG) can facilitate axonal regeneration after a complete spinal cord transection in rats, leading to improved hindlimb function. The resea...
KEY FINDING: OEG-injected rats showed recovery of motor evoked potentials (MEP), indicating functional regeneration of axons across the complete spinal cord transection.
Journal of Tissue Engineering, 2010 • October 18, 2010
The review summarizes recent clinical trials involving pharmacological treatments and cell transplantations for spinal cord injury (SCI) patients. It evaluates recent in vivo studies focusing on vario...
KEY FINDING: Methylprednisolone can improve motor and sensory functions if applied within 8 hours of SCI, but it has detrimental effects and insufficient evidence.