Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 2,181-2,190 of 2,298 results
Neurorehabil Neural Repair, 2008 • March 1, 2008
This study investigates the effect of Nogo-66 receptor antagonist peptide (NEP1-40) on functional recovery and axonal growth after lateral funiculus injury in adult rats. The results showed that NEP1-...
KEY FINDING: NEP1-40 treatment led to recovery in gait compared to controls.
Cell Mol Neurobiol, 2008 • December 6, 2007
The study aimed to observe the effect of ultrashortwave (USW) therapy on nerve regeneration after acellular nerve allografts (ANA) repairing the sciatic nerve gap of rats. USW therapy can promote nerv...
KEY FINDING: USW therapy can increase nerve conductive velocity compared to acellular nerve allografts alone.
The Journal of Neuroscience, 2008 • January 16, 2008
The study examines the electrophysiological and molecular changes in reticulospinal (RS) neurons of larval lampreys following spinal cord injury, specifically focusing on the effects of axotomy on fir...
KEY FINDING: Axotomized RS neurons initially display altered firing patterns, including single short bursts or short repetitive bursts, in response to sustained depolarization.
Exp Neurol, 2008 • February 1, 2008
This study was a replication of a previous study to determine if treatment with NEP1-40 enhances growth of corticospinal and serotonergic axons and enhances locomotor recovery after thoracic spinal co...
KEY FINDING: Treatment with NEP1-40 did not robustly enhance regenerative growth of CST axons or 5HT axons.
The Journal of Neuroscience, 2008 • January 30, 2008
This study identifies netrin-1 as a novel oligodendrocyte-associated inhibitor of axonal growth in the adult spinal cord. Netrin-1 and its receptors are expressed in the intact and lesioned adult CNS....
KEY FINDING: Netrin-1 is expressed by mature oligodendrocytes in the adult spinal cord and is enriched near paranodal loops in nodes of Ranvier.
Neuroscience, 2008 • March 18, 2008
This study investigated the fate of intramedullary primary sensory projections following a motor efferent lesion in rats. The results showed that unilateral avulsion of lumbosacral ventral roots leads...
KEY FINDING: Ventral root avulsion (VRA) induces degeneration of primary afferent collaterals in the dorsal funiculus in the absence of a direct injury to sensory axons.
Exp Neurol, 2008 • April 1, 2008
The study examined whether manipulating a spinal cord contusion injury site prior to transplantation affects behavioral recovery and axonal regeneration. Aspiration of the injury site was performed at...
KEY FINDING: Manipulation of a contusion injury site prior to transplantation does not cause long-lasting forelimb or hindlimb behavioral deficits.
Nat Neurosci, 2008 • April 1, 2008
Systemic artemin treatment caused the regeneration of damaged axons, resulting in virtually complete and long-lasting restoration of nociceptive and sensorimotor functions. Artemin, given in six syste...
KEY FINDING: Systemic artemin administration promotes the regrowth of both myelinated and unmyelinated axons through the dorsal root entry zone (DREZ).
Exp Neurol, 2008 • May 1, 2008
This study investigated the efficacy of microinjecting ChABC directly into the injury site in a rat model of spinal cord injury, using a peripheral nerve graft (PNG) to bridge the injury. The results ...
KEY FINDING: Microinjection of ChABC resulted in extensive CSPG digestion around the injury site.
The Journal of Neuroscience, 2008 • April 9, 2008
The study examined myelin status in spared axons after spinal cord injury in mice, finding that these axons are largely remyelinated by 12 weeks post-injury. This indicates a positive correlation betw...
KEY FINDING: Spared rubrospinal tract (RST) axons of passage were fully remyelinated 12 weeks after mouse spinal cord contusion injury.