Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 2,191-2,200 of 2,298 results
Stroke, 2008 • September 1, 2008
The study demonstrated that corticospinal tract fibers originating from the contralesional motor cortex sprout into the denervated spinal cord after stroke and bone marrow stromal cells treatment. BMS...
KEY FINDING: Stroke reduced the stimulation threshold evoking ipsilateral forelimb movement.
Exp Neurol, 2008 • November 1, 2008
This study investigated the effects of TGF-α infusion on astrocyte response and axonal growth following spinal cord injury in mice. TGF-α modified the physical hurdle of the scar by transforming the a...
KEY FINDING: TGF-α infusion promoted extensive axon growth into the lesion site following spinal cord injury in mice.
PLoS Biology, 2008 • July 22, 2008
The study uses genetic fate mapping to show that ependymal cells lining the central canal of the adult spinal cord act as neural stem cells in vitro and contribute extensively to the glial scar in viv...
KEY FINDING: Close to all in vitro neural stem cell potential in the adult spinal cord resides within the population of ependymal cells lining the central canal.
Neurosci Lett, 2008 • October 10, 2008
The study examined the combined effects of FGF-2 gene therapy and voluntary exercise on axonal regeneration across peripheral nerve gaps in rats. Schwann cells (SCs) were transplanted into nerve gaps,...
KEY FINDING: Exercise for 7 days elevated mRNA levels of regeneration associated proteins (GAP-43 and synapsin I) in lumbar spinal cord and dorsal root ganglia of SC transplanted, in contrast to non-cellular reconstructed rats.
Mol Cell Neurosci, 2008 • October 1, 2008
This study investigated the impact of deleting the OMgp gene on functional recovery and axonal regeneration after spinal cord injury (SCI) in mice. OMgp-/- mice on a mixed 129BL6 background exhibited ...
KEY FINDING: OMgp-/- mice on a mixed 129BL6 genetic background showed greater functional improvement compared to OMgp+/+ littermates after spinal cord injury.
The Journal of Neuroscience, 2008 • August 13, 2008
This study investigates the role of Wnt signaling in axon regeneration after spinal cord injury. It was found that normally undetectable Wnt genes are re-expressed following injury, with Wnt1 and Wnt5...
KEY FINDING: The study found that Wnt1 and Wnt5a, known repellents of corticospinal tract (CST) axons, were rapidly and broadly induced in the spinal cord gray matter after unilateral hemisection.
The Journal of Neuroscience, 2008 • August 20, 2008
This review discusses a study by Lasiene et al. (2008) that examined chronic demyelination in spared axons after spinal cord injury in mice, focusing on actively transporting rubrospinal tract (RST) a...
KEY FINDING: Lasiene et al. (2008) found evidence for complete remyelination of rubrospinal tract (RST) axons 12 weeks after spinal cord injury in mice.
Neuroscience, 2008 • October 15, 2008
The MRL/MpJ mouse strain, known for its regenerative abilities, was studied after spinal cord injury to see if it would result in reduced scar formation, increased axonal growth, and improved function...
KEY FINDING: MRL/MpJ mice exhibited robust axon growth within the lesion, beginning at 4 weeks post-injury.
J Neurosci Res, 2009 • February 1, 2009
This study demonstrates that human fetal cortical NSCs can be induced to express spinal motor neuron characteristics in vitro by bFGF. bFGF enhances the expression of ventral markers such as Olig2 in ...
KEY FINDING: bFGF induces human NSCs to express the motor neuron marker Hb9.
Journal of Biology, 2008 • September 19, 2008
This study investigates the effects of transplanting astrocytes derived from glial-restricted precursors (GRPs) treated with bone morphogenetic protein-4 (BMP-4) or ciliary neurotrophic factor (CNTF) ...
KEY FINDING: GDAsBMP promote axon regeneration, neuroprotection and robust recovery of function after spinal cord injury, whereas GDAsCNTF do not.