Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 2,201-2,210 of 2,298 results
Neurosci Bull, 2008 • October 1, 2008
This review summarizes the method of cell transplantation via CSF for treatment of SCI. Studies on administration of cells via CSF indicate that the method is safe and convenient. The method is more s...
KEY FINDING: Cell transplantation via CSF is a safe and convenient method for treating SCI, particularly suitable for multiple CNS lesions because it does not involve open lesions.
PLoS ONE, 2008 • October 6, 2008
This study examined the effects of human umbilical mesenchymal stem cell (HUMSC) transplantation on spinal cord regeneration in rats after complete spinal cord transection. HUMSCs were transplanted in...
KEY FINDING: Transplantation of HUMSCs led to significant improvements in locomotion three weeks after transplantation, compared to the control group.
Cell Mol Neurobiol, 2009 • October 17, 2008
The study successfully cloned the full-length PDGF-C gene from Gekko japonicus and analyzed its sequence, revealing similarities to PDGF-C in other species. Expression analysis showed that PDGF-C is w...
KEY FINDING: The PDGF-C gene of Gekko japonicus was cloned and found to have a transcript size of 2.8 kb.
Exp Neurol, 2009 • January 1, 2009
This study investigated the potential of IGF-I gene delivery to promote corticospinal axon regeneration and neuronal survival after spinal cord injury in adult rats. IGF-I secreting cell grafts were u...
KEY FINDING: IGF-I secreting cell grafts promoted growth of raphespinal and coerulospinal axons into the lesion/graft site after C3 dorsal column transections in adult rats.
Journal of Biology, 2008 • October 15, 2008
The review discusses the concept of using cellular bridges to repair spinal cord injuries, focusing on the challenges and potential of using different types of glial cells. It highlights research iden...
KEY FINDING: Certain astrocytes derived from glial-restricted precursors treated with BMP-4 promote spinal cord repair by integrating into host tissue, suppressing scar formation, and encouraging axon regeneration.
Spine (Phila Pa 1976), 2008 • November 15, 2008
This study evaluates the stability of implanted scaffolds and the extent of kyphoscoliotic deformities after spinal fixation in a rat model of spinal cord injury. The researchers implanted radio-opaqu...
KEY FINDING: Spinal fixation significantly reduced scoliosis in the fixed group (1.89 ± 0.75°) compared to the unfixed group (8.13 ± 2.03°).
Molecular Therapy, 2009 • February 1, 2009
The study engineered plasmid-loaded multiple channel bridges for spinal cord regeneration. These bridges support cellular processes and promote gene transfer at the injury site. Subcutaneous implantat...
KEY FINDING: Plasmid-loaded bridges support substantial cell infiltration and aligned cells within the channels.
J Orthop Res, 2009 • July 1, 2009
This study evaluated the effect of glial scar resection on recovery after spinal cord injury using contusion and dorsal hemisection models in rats. The results indicated that glial scar resection wors...
KEY FINDING: Glial scar resection did not significantly affect functional recovery in the dorsal hemisection model.
Neural Development, 2008 • December 8, 2008
This study investigates the role of Semaphorin-6A (Sema6A) and its receptors, Plexin-A2 (PlxnA2) and Plexin-A4 (PlxnA4), in the guidance of corticospinal tract (CST) axons. The results show that Sema6...
KEY FINDING: Sema6A mutants exhibit hypoplasia and misrouting of the corticospinal tract, affecting the number of axons reaching the hindbrain and spinal cord.
Drug Discov Today Dis Models, 2007 • January 1, 2007
Mammals have a limited capacity for heart regeneration, unlike zebrafish. Zebrafish can regenerate heart tissue after injury, making them a valuable model for studying cardiac regeneration. Zebrafish ...
KEY FINDING: Zebrafish heart muscle can regenerate after injury with minimal scarring, replacing lost tissue with new contractile muscle.