Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 2,261-2,270 of 2,298 results
JOURNAL OF NEUROTRAUMA, 2014 • September 15, 2014
This study demonstrates that FGF-2 administration into the spinal cord dramatically enhanced locomotor functional recovery after complete transection of the spinal cord in rats. The FGF-2-enhanced rec...
KEY FINDING: FGF-2 injection markedly improved locomotor function in rats after complete spinal cord transection.
The Journal of Neuroscience, 2010 • March 31, 2010
This study addresses the challenge of limited axon regeneration after CNS injury due to myelin and glial scar inhibition. A chemical screen of a novel triazine library identified four compounds that o...
KEY FINDING: A chemical screen identified four novel triazine compounds (A05, C05, F05, and H08) that overcome myelin-mediated inhibition of neurite outgrowth.
Curr Opin Neurobiol, 2010 • August 1, 2010
The review addresses the challenge of why injured axons in the adult mammalian CNS fail to regenerate after injury. It discusses the limitations of solely targeting extracellular inhibitory molecules ...
KEY FINDING: Removing extracellular inhibitory activities is insufficient for successful axon regeneration in the adult CNS.
The Journal of Clinical Investigation, 2010 • May 1, 2010
This study investigates the mechanisms by which folate promotes CNS axon regeneration after injury in rodents, focusing on the role of DNA methylation. The research demonstrates that injury induces Fo...
KEY FINDING: Spinal cord and peripheral nerve injury induces the expression of the high-affinity folate receptor Folr1, but not the low-affinity reduced folate carrier Rfc1.
Proc. Jpn. Acad., Ser. B, 2010 • January 4, 2010
This review summarizes recent progress in basic stem cell biology, including the identification of NSCs, the mechanisms of ontogenic changes in NSC differentiation potential, the induction of neural f...
KEY FINDING: NSCs are defined as undifferentiated cells that can both self-renew and generate the three major cell types that constitute the CNS, i.e. neurons, astrocytes, and oligodendrocytes, a characteristic known as multipotency.
Exp Neurol, 2010 • August 1, 2010
The study investigated the effects of peripheral nerve grafts (PNG) and acidic fibroblast growth factor (αFGF) combined with step training on locomotor performance in rats with complete spinal cord tr...
KEY FINDING: PNG plus αFGF treatment resulted in a clear improvement in locomotor performance with or without step training.
J. Comp. Neurol., 2010 • March 23, 2010
This study used lampreys to investigate the regeneration of synapses after spinal cord injury, focusing on the giant reticulospinal (RS) neurons. The key finding was that despite robust functional rec...
KEY FINDING: Regenerated giant RS axons produced very few synapses compared to control axons, particularly within and distal to the lesion scar.
Cold Spring Harb Perspect Biol, 2010 • January 1, 2010
Injury to the adult spinal cord causes substantial damage and often leads to permanent functional deficits. Research aims to re-establish neuronal connectivity lost after injury, which may involve sho...
KEY FINDING: Axon guidance molecules, initially important for neural development, are also present in the mature CNS, influencing network refinement, neuronal excitability, and synaptic function.
BMC Neuroscience, 2010 • June 4, 2010
The study examines the intrinsic post-axotomy response of thoracic propriospinal (TPS) neurons following spinal cord injury (SCI), focusing on changes in gene expression at different time points. The ...
KEY FINDING: A strong and early upregulation occurs in the expression of genes involved in the immune/inflammatory response that returned towards normal by 1-week post-injury.
PNAS, 2010 • June 22, 2010
The study examines the topographic specificity of sensory axon regeneration in the spinal cord following dorsal root crush, using soluble Nogo receptor peptide (sNgR) and artemin (ART) treatments. sNg...
KEY FINDING: Artemin (ART) treatment promotes topographically specific regeneration of sensory axons after dorsal root crush, while soluble Nogo receptor peptide (sNgR) does not.