Browse the latest research summaries in the field of research methodology & design for spinal cord injury patients and caregivers.
Showing 571-580 of 607 results
JOR Spine, 2024 • January 1, 2024
This study examines the impact of repetitive violent injuries on intervertebral disc degeneration (IVDD) using an organ culture model. The results indicate that repetitive high-force loading leads to ...
KEY FINDING: Repetitive one strike loading led to early disc degeneration, indicated by decreased dynamic compression stiffness.
Brain Res, 2015 • September 4, 2015
This review discusses the California Spinal Cord Consortium's (CSCC) work in developing a translational non-human primate model for spinal cord injury (SCI). The CSCC employs a biomedical informatics ...
KEY FINDING: The study highlights the development of a comprehensive preclinical data record for non-human primate SCI studies, including functional behavior, electrophysiology, kinematics, in vivo MRI, postmortem histopathology, and a full medical record.
PLoS ONE, 2013 • August 30, 2013
The BC ACT Model V1.0 was developed using discrete-event simulation to evaluate the impact of clinical and administrative interventions along the entire tSCI continuum of care. The model incorporates ...
KEY FINDING: The simulation model can estimate the impact of interventions, showing both direct and indirect effects across the continuum of care.
Neural Development, 2014 • May 22, 2014
This study investigates the transcriptome-wide response to spinal cord injury in regenerative (R-) and non-regenerative (NR-) stages of Xenopus laevis to identify mechanisms underlying successful rege...
KEY FINDING: Regenerative tadpoles showed extensive transcriptome changes at 1 day after injury, while non-regenerative froglets showed changes at 6 days after injury, indicating different kinetics in the responses.
Cell Tissue Res, 2018 • January 1, 2018
Neural stem cells (NSCs) are the stem cells of the nervous system. During development they give rise to the entire nervous system. Because NSCs are regulated by both intrinsic genetic and epigenetic p...
KEY FINDING: During development, the central nervous system (CNS) is generated from a small number of neural stem cells (NSCs) lining the neural tube.
The Journal of Spinal Cord Medicine, 2013 • March 1, 2013
The study compared life satisfaction and values among people with SCI in India, Vietnam, and Sri Lanka, finding Vietnamese participants reported higher life satisfaction. Demographic factors and livin...
KEY FINDING: People with SCI in Vietnam reported significantly higher general life satisfaction compared to those in India and Sri Lanka.
The Journal of Experimental Medicine, 1913 • January 1, 1913
This study demonstrates the successful in vitro cultivation of axis cylinders from the brains of chick embryos and young mammals, including cats, rabbits, and dogs. The cultivated nerve fibers exhibit...
KEY FINDING: Axis cylinders can be successfully cultivated in vitro from the brains of chick embryos, young cats, rabbits, and dogs.
Arch Phys Med Rehabil, 2012 • October 1, 2012
The study aimed to develop a comprehensive, patient-reported measure of physical functioning for individuals with SCI. The researchers created the Spinal Cord Injury – Functional Index (SCI-FI) throug...
KEY FINDING: A five-factor model of physical functioning (basic mobility, ambulation, wheelchair mobility, self-care, and fine motor skills) best describes the abilities of individuals with SCI.
PLoS ONE, 2014 • January 20, 2014
This study utilizes a high-density microarray to profile the temporal transcriptome dynamics during spinal cord regeneration in zebrafish, identifying 3842 differentially expressed genes. Cluster anal...
KEY FINDING: A total of 3842 genes were found to be differentially expressed during spinal cord regeneration, with maximum numbers of genes differentially expressed at 7 days post injury.
Arch Phys Med Rehabil, 2013 • September 1, 2013
The study developed a comprehensive item pool for assessing physical function within SSA disability programs, using literature review, expert input, and stakeholder interviews. Factor analysis identif...
KEY FINDING: The final item pool consisted of 139 items representing various physical activities.