Spinal Cord Injury Research
Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 2,711-2,720 of 7,812 results
Thrombin induces morphological and inflammatory astrocytic responses via activation of PAR1 receptor
Cell Death Discovery, 2022 • April 28, 2022
This study investigates the effects of thrombin, a serine protease, on astrocytes following spinal cord injury (SCI) in rats. SCI leads to increased thrombin levels, which activate protease-activated ...
KEY FINDING: Thrombin reverses astrocytic stellation, promoting proliferation but inhibiting migration.
Ultra-early Spinal Decompression Surgery Can Improve Neurological Outcome of Complete Cervical Spinal Cord Injury; a Systematic Review and Meta-analysis
Archives of Academic Emergency Medicine, 2022 • January 31, 2022
This meta-analysis investigated the efficacy of ultra-early decompression surgery (within 12 hours) compared to early or late surgery for spinal cord injuries. The study found that ultra-early surgery...
KEY FINDING: Ultra-early decompression surgery significantly improves patients’ neurological status compared to early or late decompression surgery.
Identification of a circRNA-mediated comprehensive ceRNA network in spinal cord injury pathogenesis
Experimental Biology and Medicine, 2022 • June 1, 2022
The study identifies differentially expressed immune-related genes (DEIRGs) and their ceRNA mechanisms in spinal cord injury (SCI) pathogenesis using microarray datasets and a rat SCI model. Bioinform...
KEY FINDING: Hsa_circ_0026646 was identified as a core circRNA upregulated in SCI, potentially acting as a 'molecular sponge' for miR-331-3p.
Translation, cross-cultural adaptation, and analysis of the measurement properties of the Brazilian Portuguese version of the spinal cord injury pain instrument
Spinal Cord, 2022 • April 12, 2022
The study successfully translated and adapted the SCIPI for use in Brazil. The adapted SCIPI demonstrated strong reliability and validity in assessing neuropathic pain among individuals with spinal co...
KEY FINDING: The Brazilian version of the SCIPI demonstrated adequate structural validity, confirming its one-dimensional structure.
Electroacupuncture Inhibits NLRP3 Activation by Regulating CMPK2 After Spinal Cord Injury
Frontiers in Immunology, 2022 • March 24, 2022
This study aimed to evaluate the expression of CMPK2 and activation of the NLRP3 inflammasome in rats with SCI and to characterize the effects of electroacupuncture on CMPK2-associated regulation of th...
KEY FINDING: Spinal cord injury significantly increased the expression levels of both NLRP3 and CMPK2 in the spinal cords of rats.
An Exploratory EEG Analysis on the Effects of Virtual Reality in People with Neuropathic Pain Following Spinal Cord Injury
Sensors, 2022 • March 29, 2022
This study investigates the impact of virtual reality (VR) on neuropathic pain (NP) in individuals with spinal cord injury (SCI) by analyzing changes in brain activity using electroencephalography (EE...
KEY FINDING: There was an increase in delta activity in frontal regions for 3D VR with a decrease in theta activity.
Telerehabilitation for individuals with spinal cord injury in low-and middle-income countries: a systematic review of the literature
Spinal Cord, 2022 • April 11, 2022
This systematic review evaluated existing literature about the effectiveness of telerehabilitation as an intervention for the management of SCI, focusing on LMICs. Of the five included studies, there ...
KEY FINDING: Some significant improvements to quality of life and pressure ulcer management were observed with telerehabilitation.
Videoconferencing in Pressure Injury: Randomized Controlled Telemedicine Trial in Patients With Spinal Cord Injury
JMIR Form Res, 2022 • April 19, 2022
This randomized controlled trial investigated the efficacy of videoconferencing for managing pressure injuries (PIs) in individuals with spinal cord injury (SCI) compared to regular outpatient care. T...
KEY FINDING: Health-related quality of life (HRQoL) showed no significant differences between the videoconference group (VCG) and the regular care group (RCG).
The contribution of bio-psycho-social dimensions on sexual satisfaction in people with spinal cord injury and their partners: an explorative study
Spinal Cord Series and Cases, 2022 • March 21, 2022
This study investigated the determinants of sexual satisfaction in individuals with SCI and their partners from a bio-psycho-social perspective. The results indicated that psycho-social factors, such ...
KEY FINDING: Women with SCI reported higher overall sexual satisfaction compared to men with SCI.
USING THE MULTIDIMENSIONAL MODEL OF ACCEPTANCE TO INVESTIGATE HOW DIFFERENT FACETS OF ACCEPTANCE ARE RELATED TO QUALITY OF LIFE FOLLOWING SPINAL CORD INJURY
J Rehabil Med, 2022 • April 20, 2022
This study investigated how the different facets of acceptance were associated with global, psychological, and physical QoL following SCI, and whether they would be significantly associated with QoL e...
KEY FINDING: The final regression models explained 46% of global QoL, 47% of psychological QoL and 31% of physical QoL.