Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 7,491-7,500 of 7,812 results
Regenerative Biomaterials, 2020 • January 1, 2020
The study successfully fabricated SC-NSC core–shell fibers using a coaxial nozzle, encapsulating SCs in an alginate hydrogel shell and NSCs in the core. SCs in the shell exhibited higher expression of...
KEY FINDING: Schwann cells (SCs) encapsulated in the alginate hydrogel shell expressed more genes of neurotrophic factors compared to those cultured in petri dishes, indicating enhanced neurotrophic support.
Frontiers in Neurology, 2020 • April 2, 2020
This study evaluated the efficacy of a combination therapy (scar removal, INDP, and fibrin glue matrix with MSCs) compared to INDP alone in rats with chronic spinal cord injury. The combination therap...
KEY FINDING: INDP alone significantly increased motor recovery in rats with chronic SCI compared to the combination therapy and control groups.
Ann Transl Med, 2020 • March 1, 2020
The study established a mouse model of SCI involving a crush injury followed by scar removal to simulate clinical treatment of SCI. The model was validated using BMS scoring, electrophysiology, and hi...
KEY FINDING: The initial crush injury model resulted in significant neurological deficits with limited natural recovery, as evidenced by behavioral scoring and electrophysiology.
Frontiers in Cellular Neuroscience, 2020 • April 3, 2020
The glial scar is primarily composed of scar-forming astrocytes and plays a crucial role in spinal cord regeneration. The glial scar plays a dual role in SCI, both protective and inhibitory, and its e...
KEY FINDING: The glial scar restricts the spread of inflammation to protect spared neural tissues after SCI.
CNS Neuroscience & Therapeutics, 2020 • July 1, 2020
This study investigated the neurogenic effects of immunization with neural-derived peptides (INDP) in rats with chronic spinal cord injury (SCI). The results demonstrated that INDP treatment led to si...
KEY FINDING: INDP treatment significantly improved both motor and sensory recovery in rats with chronic SCI compared to the control group.
Neural Regen Res, 2020 • May 11, 2020
The study aimed to analyze miRNA expression profiles and construct a miRNA regulatory pattern in a SCIRI rat model to understand the molecular mechanisms of SCIRI and facilitate the development of nov...
KEY FINDING: Several miRNAs are aberrantly expressed in rats after spinal cord ischemia-reperfusion injury (SCIRI). At 24 hours, 13 miRNAs were aberrantly expressed, including 12 upregulated miRNAs and 1 downregulated miRNA.
F1000Research, 2020 • April 22, 2020
Spinal cord injury (SCI) leads to chronic and multifaceted disability, which severely impacts the physical and mental health as well as the socio-economic status of affected individuals. Considerable ...
KEY FINDING: Gene therapy has gained promising advancement in the past decade, as six therapies have gained clinical approval for conditions such as spinal muscular atrophy or Leber’s congenital amaurosis.
Journal of Neuroinflammation, 2020 • April 13, 2020
This study investigates the role of IL-20, a proinflammatory cytokine, in spinal cord injury (SCI) in rats. The researchers examined the expression of IL-20 and its receptors after SCI and explored it...
KEY FINDING: IL-20 and its receptors are expressed in astrocytes, oligodendrocytes, and microglia in the spinal cord after SCI in rats.
Stem Cell Research & Therapy, 2020 • April 23, 2020
This study investigates the role of hepatocyte growth factor (HGF) in mesenchymal stem cell (MSC)-induced recovery in spinal cord injured (SCI) rats. The researchers found that MSCs promote neurologic...
KEY FINDING: Conditioned medium from bone marrow-derived MSCs (BMSCs) promotes neural stem cell differentiation into neurons and neurite outgrowth by inhibiting the BMP/Smad signaling pathway.
Cell Transplantation, 2020 • January 1, 2020
This case report describes stem cell-based therapy using autologous adipose tissue-derived mesenchymal stem cells (ADSCs) for chronic spinal cord injury (SCI) treatment in a domestic ferret patient. T...
KEY FINDING: Direct administration of autologous ADSCs into the damaged spinal cord area led to significant neurological and motor improvements in a ferret patient with chronic SCI.