Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 7,501-7,510 of 7,812 results
Current Neuropharmacology, 2020 • May 7, 2020
This review highlights the role of transcription factors and protein biomarkers in the progression of SCI and TBI, emphasizing their potential as therapeutic targets. Clinical observations and MRI ima...
KEY FINDING: NF-κB is a key molecule in secondary damage caused by inflammation after an injury and is essential for the inflammatory response of macrophages, microglia, and astrocytes.
CNS Neuroscience & Therapeutics, 2020 • April 20, 2020
This study investigates the effects of overexpressing the transcription factors OCT4 and KLF4 on spinal cord injury (SCI) recovery in mice. The aim was to modulate astrocyte behavior to improve outcom...
KEY FINDING: Overexpression of OCT4 and KLF4 reduces glial scar formation and increases its porosity in the lesion site after SCI.
Basic and Clinical Neuroscience, 2020 • January 1, 2020
The study evaluated the levels of Chondroitin Sulfate (CS) and Dermatan Sulfate (DS) in glial scars at different times after spinal cord injury (SCI) in rats. The results indicated that DS levels were...
KEY FINDING: Motor function assessment indicated a relative recovery over time after spinal cord injury.
Journal of Orthopaedic Surgery and Research, 2020 • May 25, 2020
This study investigated the relationship between inflammatory responses and prognosis in spinal cord injury (SCI). The researchers found that higher serum levels of IL-4 and IL-10 were associated with...
KEY FINDING: Higher serum levels of IL-4 and IL-10 are associated with a better prognosis in SCI, suggesting they could be potential biomarkers.
J Cell Mol Med, 2020 • July 1, 2020
This study developed a GFs-based delivery system (called GFs-HP) that consisted of basic fibroblast growth factor (bFGF), nerve growth factor (NGF) and heparin-poloxamer (HP) hydrogel through self-ass...
KEY FINDING: GFs-HP hydrogel promotes motor functional recovery after SCI, as shown by footprint analysis and BBB locomotion scores.
Brain, 2020 • June 1, 2020
This commentary discusses a study that investigated the use of a Nogo receptor decoy (AXER-204) to promote recovery after spinal cord injury in non-human primates. The study found that AXER-204 was sa...
KEY FINDING: AXER-204 showed no toxicity in rodents or primates.
Oxidative Medicine and Cellular Longevity, 2024 • June 6, 2024
Vitamins play a crucial role in supporting various body functions and maintaining overall health. In individuals with SCI, specific vitamins such as C, E, and A, known for their antioxidant properties,...
KEY FINDING: RA plays a vital role in neural differentiation processes in various types of stem cells, enhancing their effectiveness when combined with growth factors
Stem Cell Reports, 2020 • July 14, 2020
The study investigates cell transplantation for SCI in chronic settings, using skin-derived precursors differentiated into Schwann cells (SKP-SCs) in rats 8 weeks post-injury. SKP-SCs survived transpl...
KEY FINDING: SKP-SCs survived long-term at the site of chronic SCI, integrated into the host spinal cord, and mitigated astroglial scar formation.
Cerebral Cortex, 2020 • November 1, 2020
This study investigates the role of semaphorins in axon repulsion after spinal cord injury (SCI), identifying that the expression of multiple semaphorin family members is induced by Olig2. Genetic evi...
KEY FINDING: Expression of multiple semaphorin family members (Sema3a, Sema3b, Sema3c, Sema3d, Sema3g, Sema4c, Sema4d, Sema5a, Sema6a, and Sema6d) was elevated one week post-injury in mice.
Gene Therapy, 2021 • June 23, 2020
This study aimed to identify the optimal promoter for strong and neuron-specific transgene expression in cortical neurons, particularly layer V corticospinal neurons, using AAV1 vectors. The hSYN prom...
KEY FINDING: The mPGK and hSYN promoters activated transgenes in significantly more neurons than the sCAG and hCMV promoters.