Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 7,591-7,600 of 7,662 results
Journal of Orthopaedic Surgery and Research, 2016 • September 5, 2016
This study aimed to identify key molecular pathways involved in spinal cord injury (SCI) by analyzing gene expression profiles in rats at different time points after injury. The analysis revealed 416 ...
KEY FINDING: A total of 416 genes showed significant differential expression at all time points after SCI, suggesting their consistent involvement in the injury response.
Neural Regeneration Research, 2025 • September 1, 2025
Researchers are exploring stem cell strategies, specifically transplanting hiPSC-NS/PCs into spinal cord injured tissues, with ongoing clinical trials showing promising results. HGF administration can...
KEY FINDING: HGF-induced changes in gene expression were indicative of nerve regeneration and anti-inflammatory effects, in agreement with our earlier and simpler analysis of these RNA-seq data that then mostly neglected the time course of expression
Frontiers in Neurology, 2022 • May 20, 2022
Spinal Cord Injury (SCI) is a serious condition with limited effective treatments, often resulting in inflammation, apoptosis, autophagy, and oxidative stress. The mTOR signaling pathway plays a key r...
KEY FINDING: Quercetin has antioxidant and anti-inflammatory properties, promotes autophagy, and inhibits apoptosis, making it a potential drug for SCI.
Neural Regeneration Research, 2025 • July 29, 2024
This review examines the therapeutic strategies targeting the C–C motif chemokine ligand 2/C–C motif chemokine receptor 2 axis, along with the regenerative and repair mechanisms linking the axis to sp...
KEY FINDING: The CCL2/CCR2 axis recruits immune cells to the injury site, stimulating microglia and macrophages, which exacerbates the inflammatory response and nerve damage, worsening SCI.
Computational and Mathematical Methods in Medicine, 2016 • March 28, 2016
This study presents a mathematical model to investigate axon regeneration around glial scars after spinal cord injury, focusing on the impact of inhibitory factors and scar size. The model, based on S...
KEY FINDING: The level of inhibitory factors on the surface of glial scar significantly impacts axon elongation.
Glia, 2017 • December 1, 2017
This study identifies PAR2 as a key regulator of myelin development, resiliency, and regeneration in the central nervous system (CNS). The absence of PAR2 leads to increased myelin production during d...
KEY FINDING: Genetic deletion of PAR2 accelerates myelin production, resulting in higher levels of myelin-related proteins and thicker myelin sheaths.
Spinal Cord Series and Cases, 2017 • October 3, 2017
This survey has addressed the current use, perceived usefulness, and recommendations for modification to the current edition of the ISAFSCI. The survey results revealed the need to further educate clin...
KEY FINDING: Only a small percentage of respondents use the ISAFSCI regularly in their clinical practice.
Journal of Biological Chemistry, 2010 • January 8, 2010
The study identifies FM19G11 as a novel HIF inhibitor that selectively targets HIF proteins without significant cytotoxicity. FM19G11 promotes oligodendrocyte differentiation under hypoxic conditions ...
KEY FINDING: FM19G11 inhibits HIF1α and HIF2α protein accumulation in human tumor cell lines and stem cells from rodents and humans.
International Journal of Molecular Sciences, 2016 • December 26, 2016
Stem cells represent a promising therapeutic approach for SCI, enhancing sensory and motor functions in animal models by promoting remyelination and axonal regeneration. Challenges remain in stem cell...
KEY FINDING: Stem cells can promote remyelination, neurite outgrowth, and axonal elongation after spinal cord injury.
Eur J Neurosci, 2012 • July 1, 2012
This study aimed to determine if variations in step training could improve locomotor recovery in spinal cord-injured rats. Rats were trained to step forward, sideward, or backward after spinal cord tr...
KEY FINDING: Rats trained in sideward and backward stepping showed greater step consistency and coordination during forward stepping compared to forward-trained rats.