Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 7,731-7,740 of 7,812 results
TheScientificWorldJOURNAL, 2009 • June 12, 2009
The use of murine models of SCI has drastically increased in the last decade and, again, significant findings were made in 2008. Insights were provided into mechanisms underlying secondary degeneratio...
KEY FINDING: Two new mouse models of SCI using either graded forceps or Allen’s weight drop system were developed.
J. Anat., 2009 • June 24, 2009
This study investigated the effect of cyclosporin A (CsA) on functional recovery and the cellular environment following spinal cord contusion injury in rats. CsA was administered to rats after a moder...
KEY FINDING: CsA treatment resulted in a short-term functional improvement at 3 weeks post-injury in the left hindlimbs of rats.
Exp Neurol, 2009 • November 1, 2009
The study developed a rat model of cervical contusion SCI using the Infinite Horizons device, creating mild and moderate injuries at different cervical levels. The injuries resulted in varying degrees...
KEY FINDING: Rats can survive significant bilateral cervical contusion injuries at or below C5.
JOURNAL OF NEUROTRAUMA, 2009 • December 1, 2009
This study investigated the temporospatial expression and cellular localization of OMgp following traumatic SCI in adult rats using a newly developed OMgp polyclonal antibody. The research found that ...
KEY FINDING: OMgp was almost exclusively expressed in the CNS, with slight expression in cardiac muscle and liver. It was not found in lung, kidney, or skeletal muscle.
The Journal of Neuroscience, 2009 • July 8, 2009
This study re-evaluated the role of Nogo, a myelin-derived neurite growth inhibitor, in corticospinal tract (CST) regeneration after spinal cord injury in mice, addressing inconsistencies in previous ...
KEY FINDING: Neither the reanalyzed Nogo-A,B gene-trap mutant nor the novel Nogo deletion mutant exhibited enhanced corticospinal tract (CST) regeneration after experimental spinal cord injury.
Biotechnol Bioeng, 2009 • December 15, 2009
This study investigated whether delayed treatment of spinal cord injury with controlled release of neurotrophin-3 (NT-3) from fibrin scaffolds can stimulate enhanced neural fiber sprouting. The additi...
KEY FINDING: The addition of 500 ng/ mL of NT-3 with the delivery system resulted in an increase in neural fiber density compared to fibrin alone.
Molecular Therapy, 2009 • July 21, 2009
The study demonstrates that lentiviral delivery of DNROCK to neurons can effectively target the RhoA-ROCK signal pathway, promoting regenerative sprouting of injured axons after CNS injury. DNROCK enh...
KEY FINDING: DNROCK expression in DRG neurons promotes neurite growth on myelin proteins in vitro, overcoming the inhibitory effects of CNS myelin.
JOURNAL OF NEUROTRAUMA, 2009 • December 1, 2009
This study investigates the efficacy of FTY720, an immunomodulatory drug, in reducing inflammation and promoting functional recovery in a rat model of spinal cord injury (SCI). The hypothesis is that ...
KEY FINDING: FTY720 treatment significantly reduced the infiltration of CD4+ T-helper cells and CD8+ cytotoxic T-cells into the spinal cord lesion site after injury, as shown by flow cytometry.
Nat Neurosci, 2009 • September 1, 2009
This study demonstrates the reinnervation of brainstem targets after SCI and the essential role of chemotropic axon guidance in target selection. Regenerating axons in the injured adult CNS utilized c...
KEY FINDING: NT-3 expression in the correct target (nucleus gracilis) led to reinnervation in a dose-related fashion.
JOURNAL OF NEUROTRAUMA, 2009 • October 1, 2009
This study evaluated the effect of buprenorphine on molecular, behavioral, electrophysiological, and histological levels after SCI in rats. The rats were injured at the T10 thoracic level and half rec...
KEY FINDING: Microarray analysis showed no significant difference in gene expression between rats treated with buprenorphine and the control group at 2 and 4 days post-injury (DPI).