Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 7,741-7,750 of 7,812 results
JOURNAL OF NEUROTRAUMA, 2009 • December 1, 2009
This study examines the effect of ChABC on promoting axonal sprouting rostral or caudal to spinal cord injuries and its impact on functional recovery. The study found that ChABC promotes sprouting of ...
KEY FINDING: ChABC injection rostral to a hemisection injury promoted significant sprouting of 5HT+ fibers into the dorsal and ventral horns of the spinal cord.
Respir Physiol Neurobiol, 2009 • November 30, 2009
Neural and non-neural tissue and cell transplantation have been used to study CNS injury mechanisms, plasticity, regeneration, and recovery of function. Successful functional recovery after CNS injuri...
KEY FINDING: Peripheral nerve transplantation can promote CNS axon regeneration if the environment is suitable.
Glia, 2010 • February 1, 2010
This study investigates the molecular mechanisms underlying the upregulation of CHL1 expression in reactive astrocytes following spinal cord injury (SCI). It demonstrates that bacterial lipopolysaccha...
KEY FINDING: LPS upregulates CHL1 expression in astrocytes via a PI3K/PKCδ-dependent pathway.
The Journal of Neuroscience, 2009 • August 12, 2009
This study investigates how to prevent macrophage-induced retraction of dystrophic adult sensory neurons after CNS injury, using an in vitro model of the glial scar. The researchers found that proteas...
KEY FINDING: General inhibition of matrix metalloproteinases and specific inhibition of MMP-9 prevented macrophage-induced axonal retraction.
JOURNAL OF NEUROTRAUMA, 2010 • January 1, 2010
This manuscript presents a comprehensive review of biomaterial-scaffold design strategies currently being applied to the development of nerve guidance channels and hydrogels that more effectively stim...
KEY FINDING: Nerve guidance channels prevent fibrous scar tissue ingrowth, concentrate neurotrophic molecules, and direct growth from the proximal to the distal nerve stump.
Exp Neurol, 2009 • November 1, 2009
The Forelimb Locomotor Assessment Scale (FLAS) is introduced to assess forelimb use during locomotion in rats with cervical spinal cord injuries, focusing on movements, coordination, and compensatory ...
KEY FINDING: Recovery of shoulder and elbow joint movement occurred rapidly within 1–7 days post-injury, whereas recovery of wrist joint movement was slower and more variable.
Respir Physiol Neurobiol, 2009 • November 30, 2009
This review highlights current tissue engineering and novel therapeutic approaches to axonal regeneration following spinal cord injury. Restoration of respiratory function will be a critical applicati...
KEY FINDING: Axonal growth is supported by inherent properties of the selected polymer, the architecture of the scaffold, permissive microstructures such as pores, grooves or polymer fibres, and surface modifications to provide improved adherence and growth directionality.
The Journal of Clinical Investigation, 2009 • October 1, 2009
This study demonstrates that B cells, through antibody production, negatively impact recovery after spinal cord injury (SCI) in mice. Mice lacking B cells exhibit improved locomotor function and reduc...
KEY FINDING: Mice lacking B cells showed improved locomotor recovery and reduced lesion volume compared to wild-type mice after spinal cord injury.
The Journal of Clinical Investigation, 2009 • October 1, 2009
The commentary discusses a study that identifies a new immunopathological mechanism arising after spinal cord injury (SCI) in mice. The study demonstrates that B cells produce pathogenic antibodies th...
KEY FINDING: Spinal cord injury leads to a B cell response that produces pathogenic antibodies.
J Neurosci Res, 2010 • March 1, 2010
This study investigated the use of x-ray diffraction (XRD) as a rapid method to assess myelin integrity in fixed CNS tissues, aiming to aid research on de- and remyelination in spinal cord injury and ...
KEY FINDING: Fixation introduces variation in myelin periodicity and amount. The range in myelin periodicity (155–190 Å) and the broadened x-ray reflections show fixation-dependent effects.