Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 7,751-7,760 of 7,812 results
Molecular Therapy, 2010 • January 1, 2010
This study investigated the potential of PSA and HNK-1 mimetics to promote regeneration and functional recovery after spinal cord injury in mice. The mimetics were delivered via subdural infusions usi...
KEY FINDING: Treatment with PSA mimetic, alone or in combination with HNK-1 mimetic, improved functional outcome of compression spinal cord injury compared with the control treatment.
Clin Exp Pharmacol Physiol, 2010 • April 1, 2010
Glypican-1 is a major high-affinity ligand of the Slit proteins. Slit-2 and glypican-1 mRNA are upregulated and coexpressed in reactive astrocytes of injured adult brain, suggesting their involvement ...
KEY FINDING: Several potent inhibitors of glypican–Slit interactions were identified, including a low molecular weight periodate-oxidized heparin with no significant anticoagulant activity.
Neuron, 2009 • October 29, 2009
This study demonstrates that bridging axonal regeneration can be achieved in the adult CNS even when treatments are initiated at extended delays after spinal cord injury (SCI). Effective regeneration ...
KEY FINDING: Combinatorial therapies (peripheral nerve conditioning lesions, grafts of marrow stromal cells, and NT-3 gradients) promote axonal regeneration into and beyond a mid-cervical lesion site, even when administered 6 weeks to 15 months after SCI.
Stem Cells, 2010 • January 1, 2010
This study demonstrates that human embryonic stem cell-derived oligodendrocyte progenitor cells (hESC-derived OPCs) can provide at-level benefit to cervical spinal cord injury (SCI). Transplantation o...
KEY FINDING: Transplanted hESC-derived OPCs survived, localized to the injury site, and differentiated into mature oligodendrocytes.
PNAS, 2010 • February 23, 2010
This study addresses the challenge of delivering chABC, an enzyme that promotes nerve regeneration after spinal cord injury, by thermostabilizing it with trehalose and using a hydrogel-microtube syste...
KEY FINDING: Trehalose significantly enhances the thermal stability of chABC, allowing it to remain active at 37 °C for up to 4 weeks in vitro.
Frontiers in Molecular Neuroscience, 2009 • October 30, 2009
Loss of respiratory function is one of the leading causes of death following spinal cord injury. With the emergence of new and powerful tools from molecular neuroscience, new therapeutically relevant ...
KEY FINDING: Pharmacological intervention which can increase central respiratory drive might be a potential way to induce recovery of the ipsilateral hemidiaphragm following C2 hemisection – without contralateral phrenicotomy.
Journal of Biological Chemistry, 2010 • January 8, 2010
The study identifies FM19G11 as a novel HIF inhibitor that selectively targets HIF proteins without significant cytotoxicity. FM19G11 promotes oligodendrocyte differentiation under hypoxic conditions ...
KEY FINDING: FM19G11 inhibits HIF1α and HIF2α protein accumulation in human tumor cell lines and stem cells from rodents and humans.
J Neurosci Res, 2010 • May 1, 2010
The study investigates the potential of neural restricted precursors (NRP) and glial restricted precursors (GRP) to generate specific neuronal phenotypes in the injured spinal cord and extend axons to...
KEY FINDING: NRP/GRP grafts can generate glutamatergic and GABAergic neurons in the injured spinal cord, which are essential for repairing local interneuron circuits damaged by SCI.
J Neuropathol Exp Neurol, 2009 • December 1, 2009
This study investigated the therapeutic potential of olfactory bulb ensheathing glia (OB-OEG) for repairing chronic spinal cord injuries (SCI) in rats. Rats with complete SCI received OB-OEG transplan...
KEY FINDING: OB-OEG transplantation in rats with chronic SCI led to progressive improvement in motor function.
J Neurosurg Spine, 2009 • October 1, 2009
This study examines surgical methods to reduce scar and cyst formation in complete transection SCI models in rats, focusing on the influence of vasculature disruption. Dural closure with sutures signi...
KEY FINDING: Dural closure using sutures resulted in significantly less glial scar formation compared to leaving the dura open.