Browse the latest research summaries in the field of urology for spinal cord injury patients and caregivers.
Showing 341-350 of 389 results
Neurourol Urodyn, 2011 • April 1, 2011
The study examined the patterns of axonal regrowth to the bladder following different nerve repair and transfer techniques in a canine model. Postmortem DiI tracing revealed that reinnervation, irresp...
KEY FINDING: Reinnervation of the bladder, regardless of the nerve source, results in innervation of both intramural ganglia and direct innervation of the detrusor muscle.
Brain Res, 2011 • October 18, 2011
This study investigates the effectiveness of a combination therapy involving acute administration of NBQX (an AMPA/kainate receptor antagonist) and delayed transplantation of neuronal precursors (NRP/...
KEY FINDING: The combined treatment (NBQX & NRP/GRP) accelerated the recovery of bladder contraction after spinal cord injury compared to controls.
Journal of Visualized Experiments, 2012 • August 9, 2012
The study focuses on evaluating biomaterials for bladder augmentation using cystometric analyses in rodent models. Surgical implantation of gastrointestinal segments, the primary treatment for bladder...
KEY FINDING: Variations in structural and mechanical implant properties can influence the urodynamic features of tissue-engineered bladders.
Biomaterials, 2014 • August 1, 2014
The study evaluated bi-layer silk fibroin (SF) scaffolds and small intestinal submucosa (SIS) matrices for bladder tissue regeneration in a rat model of spinal cord injury (SCI). Both SF and SIS scaff...
KEY FINDING: Both bi-layer SF and SIS scaffolds supported the formation of new smooth muscle layers with contractile protein expression and maturation of multi-layer urothelia.
Neural Regeneration Research, 2014 • June 1, 2014
This study aimed to determine if long-term anode block electrical stimulation causes damage to the sacral nerve root in rabbits with complete spinal cord injury. The results indicated that the structu...
KEY FINDING: The structure of nerve cells in the anterior sacral nerve roots was unchanged in spinal cord injury rabbits after electrical stimulation, compared with normal rabbits.
Neural Regeneration Research, 2014 • October 1, 2014
The study investigates the effect of brachial plexus root avulsion (BPRA), with or without spinal cord injury (SCI), on erectile function in rats. Apomorphine was administered to observe changes in er...
KEY FINDING: Rats subjected to simple brachial plexus root avulsion or those subjected to brachial plexus root avulsion combined with spinal cord injury had significantly fewer erections than those subjected to the sham operation.
Journal of Physiology, 1989 • January 1, 1989
This study examined the reorganization of sympathetic pathways to the cat urinary bladder following chronic parasympathetic denervation. Hypogastric nerve stimulation after denervation elicited large ...
KEY FINDING: Chronic parasympathetic denervation leads to hypogastric nerve stimulation causing large and sustained bladder contractions, in contrast to the small transient contractions seen in intact bladders.
World J Mens Health, 2025 • January 1, 2025
This review summarizes the role of autophagy in erectile dysfunction (ED), focusing on how it affects endothelial cells, smooth muscle cells, penile fibrosis, and nerve injury. It highlights the poten...
KEY FINDING: Autophagy plays a significant role in maintaining the homeostasis of corpus cavernosum endothelial cells (CCECs) and determining their survival and death, influencing ED, particularly in diabetes mellitus-induced ED (DMED).
European Urology Open Science, 2024 • October 3, 2024
This systematic review and meta-analysis aimed to investigate the incidence of and risk factors for urinary stones in patients with spinal cord injury (SCI). The study found a high incidence of urinar...
KEY FINDING: The overall incidence of urinary stones after SCI was found to be 16.6%.
International Neurourology Journal, 2024 • December 31, 2024
This retrospective study investigates the effectiveness of implantable neuromodulation for patients with neurogenic lower urinary tract dysfunction (NLUTD) at a single institution from 2008 to 2020. T...
KEY FINDING: Neuromodulation, both sacral and pudendal, is a feasible and effective treatment option for NLUTD, with a significant percentage of patients experiencing symptom improvement.