Browse our collection of 11,526 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 3,871-3,880 of 11,526 results
Journal of Neuroinflammation, 2021 • December 1, 2021
This review provides a comprehensive overview of the inflammatory process following SCI, focusing on the timeline of cell infiltration and cytokine profiles in rodent models. Similarities and differen...
KEY FINDING: Proinflammatory cytokines TNFɑ, IL-1β, and IL-6 are key players early in the injury timeline, with significant upregulation within hours after SCI.
Exp Neurol, 2021 • December 1, 2021
This review emphasizes the importance of considering all supraspinal cell types in spinal cord injury (SCI) research, not just a few major pathways. The authors discuss how new technologies make it fe...
KEY FINDING: Most SCI research focuses on corticospinal, rubrospinal, and raphespinal pathways, neglecting many other important supraspinal populations.
Frontiers in Neurology, 2021 • November 30, 2021
The study characterized four stages of CSVD severity in SHRSP at different time points, ranging from pre-hypertensive to advanced CSVD. Quantitative analyses of brain MRI enable identification of in v...
KEY FINDING: SHRSP showed a significantly higher prevalence of small subcortical hyperintensities on T2w imaging that progressed in size and frequency with aging compared to WKY controls.
Brain Sci, 2021 • November 30, 2021
The study used RNA-sequencing to identify differentially expressed genes in fetal spinal cords from rats with retinoic acid-induced spina bifida at E15, E17, and E20. The results suggest common alterat...
KEY FINDING: The study found approximately 3000, 1000, and 300 genes were differentially expressed at E15, E17, and E20, respectively, compared to control groups.
Frontiers in Bioengineering and Biotechnology, 2021 • November 30, 2021
The study aimed to enhance the biological performance of 3D-printed Ti6Al4V implants by modifying their surface with a polydopamine (PDA) coating. In vitro results showed that the PDA coating improved...
KEY FINDING: PDA coating enhanced the hydrophilicity of 3D-printed Ti6Al4V implants.
Frontiers in Bioengineering and Biotechnology, 2021 • November 29, 2021
This study explored the relationship between adipose characteristics and pressure injury (PrI) history in full-time wheelchair users using MRI scans to examine subcutaneous and intramuscular fat. The ...
KEY FINDING: Participants with a history of PrIs had significantly darker adipose under the ischium than surrounding the ischium compared to participants without a history of PrIs.
BMJ Open, 2021 • November 29, 2021
This study protocol presents a randomised, placebo-controlled trial (VitD-SCI) to investigate the impact of 12 months of vitamin D supplementation on vitamin D status and secondary parameters in indiv...
KEY FINDING: The primary outcome is the change in vitamin D status after 12 months of supplementation.
Regenerative Biomaterials, 2022 • November 29, 2021
The study evaluated the effects of a hierarchically aligned fibrin hydrogel (AFG) on directing neuroregeneration in canine hemisected T12 spinal cord injuries. Histological analysis showed obvious whi...
KEY FINDING: AFG implantation induced histologically obvious white matter regeneration, consisting of a large area of consecutive, compact, and aligned nerve fibers in canine T12 spinal cord injuries.
Journal of Clinical Medicine, 2021 • November 28, 2021
This study evaluated various indices of glucose metabolism in individuals with chronic motor complete SCI to determine their agreement with IVGTT-measured insulin sensitivity (Si). The findings indica...
KEY FINDING: QUICKI (Quantitative Insulin-sensitivity Check Index) showed the strongest agreement with insulin sensitivity (Si) as measured by the IVGTT.
Evidence-Based Complementary and Alternative Medicine, 2021 • November 27, 2021
The study investigates the effects of low-intensity focused ultrasound (LIFU) on spinal cord neurocircuits in rats. LIFU stimulation of the L4-L5 spinal cord segments enhanced soleus muscle contractio...
KEY FINDING: LIFU stimulation at intensities greater than 0.5 MPa induced soleus muscle contraction and increased EMG amplitudes, indicating activation of spinal cord neurocircuits.