Latest Research Summaries

KEY FINDING: ESC-derived cells have shown efficacy in acute SCI models in animals, suggesting potential for human therapies, but require further optimization and safety measures to address tumorigenic risks.

KEY FINDING: Ependymal cells activate STAT3 and ERK/MAPK signaling pathways post-spinal cord injury, indicating a response to the injury at the molecular level.

KEY FINDING: AML-EVs showed a significant dose-dependent inhibition of T cell proliferation, unlike AML cells or their soluble factors.

KEY FINDING: In mice, immune cell recruitment precedes microglial and astrocytic responses. A complex molecular crosstalk orchestrates the formation of a well-defined and dense glial scar.

KEY FINDING: Endogenous NSCs can contribute to reactive gliosis by differentiating into reactive astrocytes, while in other models, they can provide new myelination and neural replacement.

KEY FINDING: Host axons regenerate into spinal NSC grafts placed into sites of SCI, forming synapses with the graft.

KEY FINDING: TNF-α, CCL2, and CXCL1 are significantly increased in the TNC region of ION-CCI rats, suggesting their involvement in trigeminal neuralgia.

KEY FINDING: People with spinal cord injury had statistically lower RBC, HCT, Hb, and PLT counts compared to the control group.

KEY FINDING: Exercise is helpful to alleviate NP intensity, recommending it as an effective alternative or complementary therapy.

KEY FINDING: A single CM administration to the cerebellum had a mild effect on the balance and motor deficits of SCA3/MJD mice.