Browse our collection of 11,526 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 3,891-3,900 of 11,526 results
Vet. Sci., 2021 • November 23, 2021
This study investigated the effectiveness of predegenerated nerve grafts in improving locomotor function in spinal cord-injured monkeys. Monkeys were trained to perform bipedal locomotion on complex r...
KEY FINDING: All operated monkeys showed significant deficits in locomotion on runways at the early postoperative period.
Curr Biol, 2021 • November 22, 2021
This study investigates the genetic mechanisms underlying the evolutionary transition from preaxial to postaxial limb polarity, focusing on the role of Gli3R activity. Experiments in mice and axolotls...
KEY FINDING: Deletion of 5’Hoxd genes in mice leads to preaxial dominant limb formation, an ancestral trait.
Molecular Neurobiology, 2022 • November 22, 2021
The study aimed to investigate the effects of endurance training on the expression of growth factors and stimulation of neurotrophin-dependent signaling pathways after spinal cord injury (SCI). Endura...
KEY FINDING: Endurance training significantly increased the expression of growth factors (BDNF, GDNF) and their receptors (TrkB, Gfrα) in the spinal cord.
Journal of Orthopaedics, 2021 • November 20, 2021
The study aimed to evaluate demographic and clinical characteristics of patients with traumatic and non-traumatic spinal cord injury (SCI) and to analyze functional outcomes after rehabilitation. The ...
KEY FINDING: NT-SCI patients were significantly older and affected by greater lesions when admitted than T-SCI ones.
Frontiers in Physiology, 2021 • November 19, 2021
This systematic review and meta-analysis investigated the effect and dose-response of FES-cycling training on spasticity in individuals with SCI. The study found that FES-cycling training significantl...
KEY FINDING: FES-cycling training significantly decreased spasticity in individuals with SCI.
Frontiers in Cell and Developmental Biology, 2021 • November 19, 2021
This study investigates the role of Mauthner cells (M-cells) in post-injury startle responses following spinal cord crush in adult goldfish. The researchers examined the morphological, behavioral, and ...
KEY FINDING: M-axons can survive for at least 468 days (∼1.3 years) after spinal cord crush, maintain regrowth, and elicit putative trunk EMG responses.
PLOS ONE, 2021 • November 18, 2021
This review separated studies utilising tSCS into two broad categories: studies evaluating neurophysiological properties of stimulation at a spinal level and those using tSCS as a therapeutic modality...
KEY FINDING: The overall quality of evidence was deemed to be poor-to-fair based on the Downs and Black Quality Checklist criteria.
Cells, 2021 • November 18, 2021
This review focuses on current research related to the secretome and the lesion-induced secretome and their roles in modulating spinal cord injury symptoms and functional recovery. MSCs are likely to ...
KEY FINDING: MSCs secrete a variety of soluble anti-inflammatory molecules, including TNF-β1, IL-13, IL-18 binding protein, CNTF, NT-3, IL-10, and IL-27, suggesting a significant immunoregulatory role.
Journal of Clinical Medicine, 2021 • November 17, 2021
This review article presented the latest evidence on targeting function with invasive and non-invasive approaches using electrical stimulation in people with SCI. The routine uses of FES/NMES in combi...
KEY FINDING: Neuromuscular electrical stimulation (NMES) and functional electrical stimulation (FES) can increase muscle mass, decrease fat mass, and decrease BF%, which can help ameliorate the obesity barrier to increased functional abilities and to improve cardiometabolic health.
International Journal of Environmental Research and Public Health, 2021 • November 17, 2021
This study analyzes the effects of robot-assisted gait (RAG) and independent over-ground gait (IOGG) on foot pressure in patients with incomplete spinal cord injury. The results indicate that RAG has ...
KEY FINDING: Robot-assisted gait resulted in lower peak foot pressure compared to independent over-ground gait in both strong and weak legs.