Browse the latest research summaries in the field of aging for spinal cord injury patients and caregivers.
Showing 131-140 of 142 results
Neural Regeneration Research, 2023 • November 9, 2022
This study demonstrates that aging impairs neurological recovery and angiogenesis following spinal cord injury (SCI) in mice. Metformin, a common drug for type 2 diabetes, was found to promote angioge...
KEY FINDING: Aging hinders neurological function recovery and blood vessel formation in the spinal cord after injury.
Frontiers in Molecular Biosciences, 2023 • June 30, 2023
This study investigated platelet activation, proteome, and transcriptome in Alzheimer’s disease (AD) patients, non-demented elderly, and young individuals to understand the molecular mechanisms underl...
KEY FINDING: AD and aged individuals had a proteomic signature suggestive of increased platelet activation compared with young controls.
The Journal of Spinal Cord Medicine, 2016 • January 1, 2016
This cross-sectional study assessed age-related variation in mobility independence among community-living wheelchair users with SCI. The study found a negative association between age and mobility ind...
KEY FINDING: Mobility independence decreases with age in wheelchair users with SCI across three domains: changing basic body position, transferring oneself, and moving around.
Frontiers in Aging Neuroscience, 2017 • September 7, 2017
The study investigated the use of combined SPECT and EEG data to improve the differential diagnosis of amnestic disorders. The researchers aimed to see if combining cerebral perfusion data with EEG c...
KEY FINDING: Combining SPECT with EEG biomarkers improved classification accuracy for aSCC vs. AD (90%), aMCI vs. AD (70%), and AD vs. DCI (100%).
AGING, 2020 • November 24, 2020
This study investigates the non-autophagic role of Atg7 on hematopoietic cells, finding that its loss reduces CD11b myeloid cellularity in mouse bone marrow. Specifically, Atg7 deletion results in the...
KEY FINDING: Atg7 deletion in the hematopoietic system reduces CD11b myeloid cellularity in mouse bone marrow, specifically affecting CD11b+Ly6G+ and CD11b+Ly6G- populations.
Aging and Disease, 2022 • April 1, 2022
This study investigates the role of CB2R in intervertebral disc degeneration (IVDD) by examining its effects on nucleus pulposus cell (NPC) senescence both in vitro and in vivo. The study found that C...
KEY FINDING: CB2R expression is decreased in degenerated nucleus pulposus (NP) tissues from both human IVDD patients and rat acupuncture IVDD models, while the expression of p16INK4a increased.
Oxidative Medicine and Cellular Longevity, 2021 • September 1, 2021
This study investigates the role of mitochondrial ROS in mechanical stress-induced disc degeneration using a one-strike loading organ culture model. The researchers found that mechanical stress leads ...
KEY FINDING: Mechanical stress induces mitochondrial dysfunction and ROS accumulation in nucleus pulposus (NP) cells. The proportion of ROS-positive cells increased significantly in the first 12 hours after mechanical stress.
BMC Geriatrics, 2016 • February 26, 2016
This study evaluated different strategies for classifying “does not do” responses to IADL questions when estimating prevalence of IADL limitations in a national survey. IADL stage prevalence estimates...
KEY FINDING: IADL stage prevalence estimates differed little across the four alternative strategies.
Spinal Cord, 2011 • June 1, 2011
The review analyzed 74 studies to assess the impact of spinal cord injury (SCI) on the aging process of various body systems. Evidence suggests premature aging in cardiovascular, endocrine, and muscul...
KEY FINDING: Premature aging appears to occur in the cardiovascular and endocrine systems after SCI, potentially due to inactivity and metabolic abnormalities.
Front. Aging Neurosci., 2023 • August 2, 2023
This study investigates the role of leukotriene (LT) signaling in cognitive heterogeneity during aging, focusing on the expression of 5-lipoxygenase (5-Lox) and 5-lipoxygenase-activating protein (FLAP...
KEY FINDING: Expression of 5-Lox was increased within the brain of aged rats, with the highest levels detected in cognitively impaired animals, suggesting a link between the LT system and cognitive decline.