Browse the latest research summaries in the field of bioinformatics for spinal cord injury patients and caregivers.
Showing 121-130 of 296 results
Molecular Oncology, 2021 • January 24, 2021
This study benchmarks HLA genotyping on TCGA data using multiple tools to generate reliable HLA genotyping results. It finds that HLA class I genotyping is generally better than class II genotyping, w...
KEY FINDING: POLY-SOLVER, OptiType, and xHLA show high accuracy in HLA class I genotyping, with accuracies of 0.954, 0.949, and 0.937, respectively.
PNAS, 2021 • April 7, 2021
This study presents the chromosome-level assembly of the giant axolotl genome, providing a valuable resource for understanding genome organization, evolution, and gene regulation in this important mod...
KEY FINDING: The chromosome-scale assembly of the 32 Gb axolotl genome was achieved using Hi-C contact data.
Journal of Neurotrauma, 2021 • August 1, 2021
The study tracked serological markers over one year following spinal cord injury, finding that most markers normalized within 6-12 months, with injury severity affecting these levels. Differences betw...
KEY FINDING: Most serological markers were at pathological levels at baseline but returned to normal values within 6–12 months post-injury.
eLife, 2021 • May 14, 2021
This study investigates the mechanisms underlying spinal cord regeneration in axolotls, focusing on the spatiotemporal pattern of cell proliferation. It demonstrates that the regenerative response is ...
KEY FINDING: Spinal cord regeneration is consistent with a signal that recruits ependymal cells during approximately 85 hours after amputation within approximately 830 μm of the injury.
J. Exp. Med, 2021 • August 2, 2021
This study used single-cell RNA sequencing to generate a detailed transcriptomic profile of cells at the spinal cord injury site. The researchers identified major cell types and their interactions dur...
KEY FINDING: The study identified distinct temporal regulation of angiogenesis, gliosis, and fibrosis by myeloid subtypes.
Frontiers in Neuroscience, 2021 • May 28, 2021
This study investigated the potential of serum SELENBP1 as a biomarker for traumatic spinal cord injury (TSCI). The researchers analyzed serum samples from patients with TSCI, comparing SELENBP1 level...
KEY FINDING: Serum SELENBP1 concentrations are elevated in patients with more severe neurological impairment (AIS A) compared to those with less severe impairment (AIS B-D) at the time of admission.
Crit Care, 2021 • June 29, 2021
This study identifies CEA as a potential biomarker for COVID-19 patients, exploring its underlying mechanism through single-cell transcriptomics. The research reveals that developing neutrophils/neutr...
KEY FINDING: CEA was identified as the only laboratory indicator with a significant difference in both univariate and multivariate analyses.
BIOENGINEERED, 2021 • August 23, 2021
This study identifies alternative splicing events associated with bladder cancer bone metastasis and constructs a predictive model for prognosis. The research proposes a regulatory mechanism involving...
KEY FINDING: Alternative splicing events (ASEs) are associated with the occurrence and progression of bladder cancer and have a relationship with its prognosis.
The EMBO Journal, 2021 • September 24, 2021
The study reveals a conserved developmental map of the human telencephalon, highlighting the temporal cell fate transition from neuroectoderm (NE) to radial glial cells (RGs) to intermediate progenito...
KEY FINDING: Dorsal and ventral telencephalons share common developmental programs during neurogenesis, following a conserved trajectory from radial glial cells (RGs) to intermediate progenitor cells (IPCs_div) and then to early neuroblasts (eNBs).
Molecular Nutrition & Food Research, 2021 • October 28, 2021
This study investigated the role of diet and gut microbiota in cognitive decline (CD) using a 12-year prospective study design involving two separate sample sets from Bordeaux and Dijon. The findings ...
KEY FINDING: Metabolites derived from cocoa, coffee, mushrooms, and red wine are associated with reduced cognitive decline.