Browse the latest research summaries in the field of bioinformatics for spinal cord injury patients and caregivers.
Showing 271-280 of 296 results
Heliyon, 2022 • October 13, 2022
This study investigates the dynamics of cartilage-derived stem/progenitor cells (CSPCs) in osteoarthritis (OA) progression using single-cell transcriptomic data. The research reveals that CSPC heterog...
KEY FINDING: CSPCs exhibit significant heterogeneity that is closely associated with the progression of OA, indicating that the characteristics of CSPCs change during OA progression.
PLoS ONE, 2014 • January 20, 2014
This study utilizes a high-density microarray to profile the temporal transcriptome dynamics during spinal cord regeneration in zebrafish, identifying 3842 differentially expressed genes. Cluster anal...
KEY FINDING: A total of 3842 genes were found to be differentially expressed during spinal cord regeneration, with maximum numbers of genes differentially expressed at 7 days post injury.
PNAS, 2017 • December 26, 2017
Glycosaminoglycans (GAGs) are important in biological processes, but structural information on their protein complexes is limited. The study introduces GAG-Dock, a computational method to predict GAG-...
KEY FINDING: The GAG-Dock method accurately reproduces the binding poses of heparin to proteins, as validated against known crystal structures.
Nutrients, 2022 • November 5, 2022
The gut microbiome is involved in nutrient metabolism and produces metabolites that, via the gut–brain axis, signal to the brain and influence cognition. Higher serum levels of propionic acid, a short-...
KEY FINDING: Higher serum levels of propionic acid were associated with increased odds of cognitive decline.
Molecular Pain, 2024 • April 1, 2024
The study analyzed alternative splicing (AS) patterns in mouse brain, dorsal root ganglion (DRG), and spinal cord tissues under inflammatory and neuropathic pain conditions to understand the molecular ...
KEY FINDING: The study identified 6495 differentially alternatively spliced (DAS) genes in the mouse brain, dorsal root ganglion, and spinal cord tissue under inflammatory and neuropathic pain.
Brain Sci, 2021 • November 30, 2021
The study used RNA-sequencing to identify differentially expressed genes in fetal spinal cords from rats with retinoic acid-induced spina bifida at E15, E17, and E20. The results suggest common alterat...
KEY FINDING: The study found approximately 3000, 1000, and 300 genes were differentially expressed at E15, E17, and E20, respectively, compared to control groups.
Clin Biomech (Bristol, Avon), 2004 • March 1, 2004
The purpose of this study was to estimate the loading environment for the distal femur during a novel standing exercise paradigm for people with spinal cord injury. A static, 2-D model was developed t...
KEY FINDING: Active-resistive stance resulted in maximal distal femur compression estimates of ~240% of body weight.
J. Pers. Med., 2023 • November 24, 2023
This study explores the use of a Generative Adversarial Network (GAN) to reconstruct 3D spinal vertebrae structures from synthetic biplanar X-ray images. The X2CT-GAN model was applied, focusing on an...
KEY FINDING: The GAN-based method can effectively reconstruct 3D spinal vertebrae structures from biplanar X-rays.
eLife, 2020 • April 27, 2020
By intersecting chromatin accessibility data with single-cell transcriptomics, we find that NPCs place an early priority on neuronal differentiation. Late in regeneration, the priority returns to prol...
KEY FINDING: NPCs place an early priority on neuronal differentiation. Late in regeneration, the priority returns to proliferation.
Bioactive Materials, 2022 • January 1, 2022
This study utilizes single-cell RNA sequencing to investigate the molecular mechanisms underlying MSC-mediated bone regeneration in different osteogenic microenvironments, specifically focusing on hyd...
KEY FINDING: HA scaffolds induce bone formation through a process similar to endochondral ossification, activating TGF-β, PTHrP, and BMP signaling pathways sequentially.