Biomedical Research

KEY FINDING: The RISES system demonstrated safety and feasibility for tSCS application in clinical settings. There were no serious adverse events and skin integrity was unaffected at stimulation sites.

KEY FINDING: The stimulation pattern derived from the SCI subject’s force output produced 14% more power than the EMG-derived stimulation pattern.

KEY FINDING: The study found no significant differences in the time spent to fully open/close the hand exoskeleton and the gripper of the robotic external manipulator through the EEG interface normalized to ERD duration.

KEY FINDING: The "combo" therapy reduced M1 microglia activation and glutamate levels in the short term, indicating a strong anti-inflammatory effect.

KEY FINDING: Human-in-the-loop optimization led to muscle activity reduction of 33.56% and 41.81% at most when compared to walking without and with the hip exoskeleton, respectively.

KEY FINDING: Dual-EV nanocarriers target human umbilical vascular endothelial cells (HUVECs) and recruit NSCs in vitro.

KEY FINDING: The porous MN-MSC patch can effectively maintain the survival of MSCs and sustainably release MSC secretome for at least one week.

KEY FINDING: There was a significant delay in the latency of the time-frequency components distributed between 15 and 30 ms and 50 and 150 Hz in all spinal cord injury groups.

KEY FINDING: Errors were identified in Figure 3 of the original article.

KEY FINDING: Viewing the knee joint as simplified geometric figures facilitates understanding ligament and muscle interactions during leg flexion and extension.