Biomedical Research

KEY FINDING: NS@COP restores the responsiveness of pro-inflammatory macrophages to CGRP by upregulating RAMP1, promoting an anti-inflammatory M2 phenotype.

KEY FINDING: G-CuNCs can assist in the fast formation of R-CuNCs, retaining their tiny size and water solubility.

KEY FINDING: Transfection efficiencies varied among the cell types tested (bCH 28.4% ± 22.87, rTDSPC 18.13% ± 12.07, hBMSC 18.23% ± 14.80, hSDSC 26.63% ± 8.81).

KEY FINDING: Electrospun PLLA scaffolds, especially those with aligned nanofibers, promote nerve cell proliferation, guide neurite extension, and modulate macrophage polarization towards anti-inflammation.

KEY FINDING: The coculture implant led to a four fold increase in functional vessels compared to the lesion control, implant alone, or implant plus NPCs groups.

KEY FINDING: Incorporating gaze-based target information significantly improves decoding accuracy compared to using EMG data alone, especially at simulated injury levels.

KEY FINDING: RGD motifs enhance cell viability and proliferation in hydrogels, making them suitable for articular cartilage regeneration.

KEY FINDING: Ce3+ ions can be used to crosslink and rearrange L-cysteine-protected copper nanoclusters into ordered mesoporous spheres.

KEY FINDING: Materials-potentiated cell engineering strategies are to endow immune cells with different supportive components (also known as backpack strategies), or functional materials to enhance their anti-tumor effects, prevent and rescue their dysfunction, maintain and restore their anti-tumor phenotype

KEY FINDING: The incorporation of C3 transferase mRNA into MP-LNPs does not compromise the structural integrity of the nanoparticles, ensuring efficient mRNA expression within the spinal cord.