Biomedical Research

KEY FINDING: Applying a downward force on the pelvis during walking leads to narrower strides and increased overall foot loading, suggesting changes in gait stability.

KEY FINDING: Acute treatment with PLG nanoparticles following thoracic SCI significantly reduces tactile and cold hypersensitivity scores in a durable fashion.

KEY FINDING: The correction clarifies that MN-MSC treatment, not MN-EV treatment, resulted in a statistically significant increase in the anti-inflammatory cytokine TGF-β.

KEY FINDING: Patients demonstrated progressive tolerance for OEGT over successive sessions, as shown by increasing time upright and walking, step count, and decreased assistance required by the exoskeleton.

KEY FINDING: The RELab tenoexo provided an immediate functional benefit to the users, resulting in a mean improvement of the ARAT score by 5.8 points.

KEY FINDING: M2-Exos-laden electroconductive hydrogels stimulate the growth of neural stem cells and axons in the dorsal root ganglion and modulate microglial M2 polarization.

KEY FINDING: The depth camera showed higher Pearson’s correlation (r > 98) and lower root mean squared error (RMSE < 10 mm) than the pressure mat (r > 0.82; RMSE < 4.5 mm) when compared with the force plate overall.

KEY FINDING: CNT/GelMA hydrogel fibers supported PC12 cell proliferation and aligned adhesion, which was enhanced by electrical stimulation (ES).

KEY FINDING: The developed neural network model exhibits an average time error of less than 11.51 ms across all walking conditions, indicating its suitability for real-time applications.

KEY FINDING: The nano complex promotes axon regrowth, modulates the local inflammatory microenvironment, and enhances functional recovery of SCI in mice, without causing treatment-related secondary injury.