Biomedical Research
Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 41-50 of 904 results
Comparison of Cellular Architecture, Axonal Growth, and Blood Vessel Formation Through Cell-Loaded Polymer Scaffolds in the Transected Rat Spinal Cord
TISSUE ENGINEERING: Part A, 2014 • August 8, 2014
This study used multichannel polymer scaffolds in a complete spinal cord transection injury model in rats to compare the effects of Schwann cells and mesenchymal stem cells (MSCs) on tissue regenerati...
KEY FINDING: Axon regeneration was significantly augmented by Schwann cell implantation, while eGFP-MSCs did not support axon growth in the transected spinal cord.
The use of bi-layer silk fibroin scaffolds and small intestinal submucosa matrices to support bladder tissue regeneration in a rat model of spinal cord injury
Biomaterials, 2014 • August 1, 2014
The study evaluated bi-layer silk fibroin (SF) scaffolds and small intestinal submucosa (SIS) matrices for bladder tissue regeneration in a rat model of spinal cord injury (SCI). Both SF and SIS scaff...
KEY FINDING: Both bi-layer SF and SIS scaffolds supported the formation of new smooth muscle layers with contractile protein expression and maturation of multi-layer urothelia.
Poly(lactic-co-glycolic) acid microspheres encapsulated in Pluronic F-127 prolong Hirudin delivery and improve functional recovery from a demyelination lesion
Biomaterials, 2014 • October 1, 2014
The study investigates the potential of thrombin inhibitors to improve cellular regeneration after spinal cord injury. PLGA microspheres and Pluronic F-127 hydrogels were used to create depot formulat...
KEY FINDING: Thrombin increases endogenous neural progenitor proliferation in the intact murine spinal cord.
Novel nanometer scaffolds regulate the biological behaviors of neural stem cells
Neural Regen Res, 2013 • June 1, 2013
This study investigated the use of aligned and randomly oriented collagen nanofiber scaffolds to regulate the biological behaviors of neural stem cells. The results indicated that novel nanofiber scaf...
KEY FINDING: The proliferation of spinal cord-derived neural stem cells on novel nanofiber scaffolds was obviously enhanced.
Can amino-functionalized carbon nanotubes carry functional nerve growth factor?
Neural Regeneration Research, 2014 • February 1, 2014
This study explored the use of amino-functionalized multi-walled carbon nanotubes (MWCNTs) to deliver nerve growth factor (NGF). The researchers prepared MWCNTs-NGF complexes and assessed their physic...
KEY FINDING: Amino functionalization improves the dispersibility of carbon nanotubes-nerve growth factor complexes.
The Effects of Controlled Release of Neurotrophin-3 from PCLA Scaffolds on the Survival and Neuronal Differentiation of Transplanted Neural Stem Cells in a Rat Spinal Cord Injury Model
PLoS ONE, 2014 • September 12, 2014
In this study, by incorporating NT-3 into a SF coating, we successfully developed NT-3-immobilized scaffolds (membranes and conduits). Furthermore, 8 weeks after the NSCs were seeded into conduits and...
KEY FINDING: NSC neuronal differentiation was 55.264.1% on the NT-3-immobilized membranes, which was significantly higher than that on the NT-3 free membrane.
A Fractal Nature for Polymerized Laminin
PLoS ONE, 2014 • October 8, 2014
The study investigates the three-dimensional structure of polylaminin (polyLM) and ordinary laminin (LM) using confocal fluorescence microscopy, scanning electron microscopy, and atomic force microsco...
KEY FINDING: Polylaminin (polyLM) forms a sponge-like network with homogeneous density, while ordinary laminin (LM) forms bulky protein aggregates.
Transactivating-transduction protein-polyethylene glycol modified liposomes traverse the blood-spinal cord and blood-brain barriers
Neural Regeneration Research, 2012 • December 1, 2012
This study aimed to analyze the delivery of a novel liposome and its ability to transport drugs across the blood-spinal cord and blood-brain barriers. The novel liposomes have a hydrophobic core for e...
KEY FINDING: The modified liposomes exhibited good biocompatibility and low cytotoxicity when cocultured with human breast adenocarcinoma cells.
Pyrroloquinoline quinone-loaded coaxial nanofibers prevent oxidative stress after spinal cord injury
Nanoscale Advances, 2025 • January 7, 2025
This study explores the use of pyrroloquinoline quinone (PQQ) loaded on coaxial nanofibers as an implantable drug-delivery system to combat oxidative stress following spinal cord injury (SCI) in rats. ...
KEY FINDING: The concentration of NO and the activity of iNOS were significantly increased in the SCI group but were significantly decreased following treatment with nanofibers/PQQ.
Usability of an exosuit in domestic and community environments
Journal of NeuroEngineering and Rehabilitation, 2022 • November 18, 2022
This study evaluated the usability of the Myosuit, an exosuit designed to assist individuals with lower limb motor impairments, in domestic and community environments. The research combined quantitati...
KEY FINDING: The Myosuit received an above-average usability score, indicating that it is generally easy to use. Participants expressed high satisfaction with most of the technical features of the Myosuit.