Brain Injury Research

KEY FINDING: The incidence of a dual diagnosis of SCI with a co-occurring TBI may approach 60–74% with certain risk factors such as a motor vehicle collision or a fall.

KEY FINDING: The UNITE study is designed to investigate the validity of proposed clinical criteria for CTE, using neuropathological findings as the gold standard.

KEY FINDING: mTBI patients, regardless of whether they show lesions on standard scans, exhibit alterations in brain network connectivity that correlate with cognitive performance six months post-injury.

KEY FINDING: The study found that rehospitalization risk decreases over time in both SCI and TBI patients.

KEY FINDING: TBI survivors often experience white matter degradation, neuronal loss, protein misfolding, and persistent neuroinflammation, contributing to long-term disabilities.

KEY FINDING: MW189 was safe and well tolerated in single and multiple doses up to 0.25 mg/kg, with infusion-site reactions being the most common adverse event.

KEY FINDING: Twenty-four articles and reports were identified; 15 unique definitions for TBI and 7 for SCI were found.

KEY FINDING: The study identified one hundred and twenty-nine researchable clinical questions in TBI and SCI. These questions were then prioritised into high (n = 60) and low (n = 69) importance by the stakeholders involved in question development.

KEY FINDING: TBI occurred in 65% of SCI individuals, but documentation of identification of TBI, LOC, and CT imaging results varied across the continuum of care.

KEY FINDING: The systematic review aims to document the course of cognitive status (decline, improvement, stability, fluctuations, etc) in patients with CNS trauma as time since injury progresses.